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Title: Apparent Diffusion Coefficient and Transient Neurological Deficit after Revascularization Surgery in Moyamoya Disease.
Authors: Araki, Yoshio
Takagi, Yasushi
Fushimi, Yasutaka  kyouindb  KAKEN_id  orcid (unconfirmed)
Arakawa, Yoshiki  kyouindb  KAKEN_id  orcid (unconfirmed)
Funaki, Takeshi  kyouindb  KAKEN_id
Kikuchi, Takayuki  kyouindb  KAKEN_id
Takahashi, Jun C
Togashi, Kaori
Miyamoto, Susumu
Author's alias: 荒木, 芳生
Keywords: Adult
moyamoya disease
revascularization surgery
transient neurological deficit
Issue Date: Sep-2015
Publisher: Elsevier Inc.
Journal title: Journal of stroke and cerebrovascular diseases
Volume: 24
Issue: 9
Start page: 2054
End page: 2059
Abstract: 【Background】Transient neurological deficits are relatively common after direct revascularization surgery for moyamoya disease (MMD). Although recent evidence has revealed the clinical features and pathophysiology, preoperative predictors have remained unclear. This study investigated whether the apparent diffusion coefficient (ADC) in normal-appearing white matter (NAWM) on magnetic resonance imaging could offer a predictor of postoperative transient neurological deficits. 【Methods】This study included adult patients with MMD who underwent superficial temporal artery-middle cerebral artery bypass. Preoperative ADCs were measured in NAWM on ipsilateral hemisphere. Single photon emission computed tomography (SPECT) with123I-iodoamphetamine was performed on postoperative days 2-6. Relationships between mean ADC and postoperative transient neurological deficits were assessed. 【Results】Results Twenty of the 26 subjects (76.9%) experienced transient neurological deficits. Focal hyperemia on postoperative SPECT appeared in 11 of the 20 subjects with postoperative transient neurological deficits and 1 of the 6 subjects without (P = .12). Mean ADCs in patients with and without postoperative transient neurological deficits were 748.3 ± 12 mm2/second × 10−6 and 679.7 ± 21.9 mm2/second × 10−6, respectively (P = .0091). 【Conclusions】Preoperative ADC elevation in NAWM may indicate postoperative transient neurological deficits not only in patients with postoperative hyperemia on SPECT, but also in patients with this pathology.
Description: Available online 10 July 2015
Rights: © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
The full-text file will be made open to the public on 10 July 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.jstrokecerebrovasdis.2015.04.026
PubMed ID: 26166418
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