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Title: High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: a report from the CREDO-Kyoto registry cohort-2.
Authors: Izuhara, Masayasu
Ono, Koh
Shiomi, Hiroki  kyouindb  KAKEN_id
Morimoto, Takeshi
Furukawa, Yutaka
Nakagawa, Yoshihisa
Shizuta, Satoshi
Tada, Tomohisa
Tazaki, Junichi  kyouindb  KAKEN_id
Horie, Takahiro  kyouindb  KAKEN_id
Kuwabara, Yasuhide  kyouindb  KAKEN_id
Baba, Osamu
Nishino, Tomohiro  kyouindb  KAKEN_id
Kita, Toru
Kimura, Takeshi  kyouindb  KAKEN_id
Author's alias: 尾野, 亘
Keywords: High-density
Lipoprotein cholesterol
Myocardial infarction
Percutaneous coronary intervention
Statin
Issue Date: Oct-2015
Publisher: Elsevier Ltd.
Journal title: Atherosclerosis
Volume: 242
Issue: 2
Start page: 632
End page: 638
Abstract: [Objective]To determine whether low HDL-C is a risk factor for adverse cardiovascular events in patients with known CAD. [Methods]We evaluated 10, 391 patients who underwent PCI from January 2005 to December 2007. In total, 3838 (36.9%) patients had low HDL-C (HDL-C <40 mg/dL in males and <50 mg/dL in females) and 6553 (63.1%) patients had normal HDL-C based on measurements on admission. [Results]The unadjusted 5-year incidence of major adverse cardiac events (MACE: composite of cardiovascular death, myocardial infarction or stroke) was significantly higher in the low HDL-C group than in the normal HDL-C group (17.6% vs. 14.0%, P < 0.0001). However, after adjusting for confounders, low HDL-C was not associated with a higher risk of MACE (adjusted hazard ratio [HR] 1.07, 95% confidence interval (CI) 0.97?1.19; P = 0.19). There was no significant interaction between the effect of low HDL-C on MACE and several subgroup factors including age, sex, clinical presentation of CAD, statins use, serum low-density lipoprotein cholesterol level, and serum triglycerides level. [Conclusion]Low HDL-C, as compared with normal HDL-C, was not associated with higher 5-year risk of MACE in patients who underwent PCI.
Rights: c 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NCND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
URI: http://hdl.handle.net/2433/202588
DOI(Published Version): 10.1016/j.atherosclerosis.2015.05.010
PubMed ID: 26022139
Appears in Collections:Journal Articles

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