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Title: 9-Oxo-10(E),12(Z),15(Z)-Octadecatrienoic Acid Activates Peroxisome Proliferator-Activated Receptor α in Hepatocytes.
Authors: Takahashi, Haruya  kyouindb  KAKEN_id
Kamakari, Kosuke
Goto, Tsuyoshi  kyouindb  KAKEN_id
Hara, Hideyuki
Mohri, Shinsuke
Suzuki, Hideyuki
Shibata, Daisuke
Nakata, Rieko
Inoue, Hiroyasu
Takahashi, Nobuyuki
Kawada, Teruo
Author's alias: 高橋, 春弥
河田, 照雄
Keywords: PPARα
Oxylipin
Hepatocytes
Fatty acid metabolism
LC–MS
Issue Date: Nov-2015
Publisher: Springer Berlin Heidelberg
Journal title: Lipids
Volume: 50
Issue: 11
Start page: 1083
End page: 1091
Abstract: The peroxisome proliferator-activated receptor (PPAR)α is mainly expressed in the liver and plays an important role in the regulation of lipid metabolism. It has been reported that PPARα activation enhances fatty acid oxidation and reduces fat storage. Therefore, PPARα agonists are used to treat dyslipidemia. In the present study, we found that 9-oxo-10(E), 12(Z), 15(Z)-octadecatrienoic acid (9-oxo-OTA), which is a α-linolenic acid (ALA) derivative, is present in tomato (Solanum lycopersicum) extract. We showed that 9-oxo-OTA activated PPARα and induced the mRNA expression of PPARα target genes in murine primary hepatocytes. These effects promoted fatty acid uptake and the secretion of β-hydroxybutyrate, which is one of the endogenous ketone bodies. We also demonstrated that these effects of 9-oxo-OTA were not observed in PPARα-knockout (KO) primary hepatocytes. To our knowledge, this is the first study to report that 9-oxo-OTA promotes fatty acid metabolism via PPARα activation and discuss its potential as a valuable food-derived compound for use in the management of dyslipidemia.
Description: First online: 19 September 2015
Rights: The final publication is available at Springer via http://dx.doi.org/10.1007/s11745-015-4071-3.
The full-text file will be made open to the public on 19 September 2016 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/203050
DOI(Published Version): 10.1007/s11745-015-4071-3
PubMed ID: 26387026
Appears in Collections:Journal Articles

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