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Title: Carbohydrate intake is associated with time spent in the euglycemic range in patients with type 1 diabetes.
Authors: Ayano-Takahara, Shiho
Ikeda, Kaori  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-2273-9693 (unconfirmed)
Fujimoto, Shimpei
Asai, Kanae
Oguri, Yasuo
Harashima, Shin-Ichi
Tsuji, Hidemi
Shide, Kenichiro
Inagaki, Nobuya  kyouindb  KAKEN_id
Author's alias: 池田, 香織
稲垣, 暢也
Keywords: Dietary carbohydrates
Glycemic control
Type 1 diabetes mellitus
Issue Date: Nov-2015
Publisher: wiley
Journal title: Journal of diabetes investigation
Volume: 6
Issue: 6
Start page: 678
End page: 686
Abstract: [Aims/Introduction]Greater glycemic variability and lack of predictability are important issues for patients with type 1 diabetes. Dietary factors are one of the contributors to this variability, but how closely diet is linked to glycemic fluctuation on a daily basis has not been investigated. We examined the association between carbohydrate intake and glycemic excursion in outpatients. [Materials and Methods]A total of 33 patients with type 1 diabetes were included in the analyses (age 44.5 ± 14.7 years, diabetes duration 15.1 ± 8.3 years, 64% female, 30% using insulin pump, glycated hemoglobin 8.1 ± 1.3%). Time spent in euglycemia (70–180 mg/dL), hyperglycemia (>180 mg/dL) and hypoglycemia (<70 mg/dL) of consecutive 48-h periods of continuous glucose monitoring data were collected together with simultaneous records of dietary intake, insulin dose and physical activity. Correlation analyses and multiple regression analyses were used to evaluate the contribution of carbohydrate intake to time spent in the target glycemic range. [Results]In multiple regression analyses, carbohydrate intake (β = 0.53, P = 0.001), basal insulin dose per kg per day (β = −0.31, P = 0.034) and diabetes duration (β = 0.30, P = 0.042) were independent predictors of time spent in euglycemia. Carbohydrate intake (β = −0.51, P = 0.001) and insulin pump use (β = −0.34, P = 0.024) were independent predictors of time spent in hyperglycemia. Insulin pump use (β = 0.52, P < 0.001) and bolus insulin dose per kg per day (β = 0.46, P = 0.001) were independent predictors of time spent in hypoglycemia. [Conclusions]Carbohydrate intake is associated with time spent in euglycemia in patients with type 1 diabetes.
Rights: © 2015 The Authors. Journal of Diabetes Investigation published by Asian Association of the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
URI: http://hdl.handle.net/2433/203051
DOI(Published Version): 10.1111/jdi.12360
PubMed ID: 26543542
Appears in Collections:Journal Articles

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