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Title: <Original Articles>Serum Cathepsin B Levels, Urinary Excretion of Cathepsin B and Tissue Cathepsin B Content in the Patients with Gastric Cancer
Other Titles: <原著>胃癌患者における血中カテプシンB値, 尿中カテプシンB排出量および組織カテプシンB含有量について
Author's alias: 平野, 鉄也
吉岡, 秀憲
Keywords: Lysosomal enzyme
Cathepsin B
Gastric cancer
カテプシン B
Issue Date: 1-Sep-1993
Publisher: 京都大学医学部外科整形外科学教室内 日本外科宝函編集室
Journal title: 日本外科宝函
Volume: 62
Issue: 5
Start page: 217
End page: 221
Abstract: Serum cathepsin B levels and urinary excretion of cathepsin B in the patients with gastric cancer were significantly higher than those in the control non-cancer patients. Moreover, cancer tissue cathepsin B content was significantly higher than that in the normal tissue. After radical curative operations for gastric cancers, both serum cathepsin B levels and urinary excretion of cathepsin B were restored to the control values. These results suggest a possible role of lysosomal enzyme, cathepsin B in the pathogenesis of tumor growth, and also suggest that these parameters might be possible indicators for tumor malignancy.
胃癌患者での血中カテプシン B 値および尿中カテプシン B 排出量はコントロールの非癌患者に比べ有意に高値を示したさらに, 切除標本での検討にて, 胃癌組織中でのカテプシン B 含有量は正常組織と比べ有意に高値を示した. 胃癌患者では, 根治手術後には, 血中カテプシン B 値も尿中カテプシン B 排出量もともにコントロール値に回復した. これらの結果は, ライソゾーム酵素であるカテプシン B の癌発育過程での何らかの役割を示唆させるとともに, これらのパラメーターが, 悪性腫瘍の指標となりうることも示唆させた.
PubMed ID: 8031215
Appears in Collections:第62巻 第5号

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