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dc.contributor.authorHIRANO, TETSUYAen
dc.contributor.authorYOSHIOKA, HIDENORIen
dc.contributor.alternative平野, 鉄也ja
dc.contributor.alternative吉岡, 秀憲ja
dc.contributor.transcriptionヒラノ, テツヤja-Kana
dc.contributor.transcriptionヨシオカ, ヒデノリja-Kana
dc.date.accessioned2016-02-03T02:27:25Z-
dc.date.available2016-02-03T02:27:25Z-
dc.date.issued1993-09-01-
dc.identifier.issn0003-9152-
dc.identifier.urihttp://hdl.handle.net/2433/203696-
dc.description.abstractSerum cathepsin B levels and urinary excretion of cathepsin B in the patients with gastric cancer were significantly higher than those in the control non-cancer patients. Moreover, cancer tissue cathepsin B content was significantly higher than that in the normal tissue. After radical curative operations for gastric cancers, both serum cathepsin B levels and urinary excretion of cathepsin B were restored to the control values. These results suggest a possible role of lysosomal enzyme, cathepsin B in the pathogenesis of tumor growth, and also suggest that these parameters might be possible indicators for tumor malignancy.en
dc.description.abstract胃癌患者での血中カテプシン B 値および尿中カテプシン B 排出量はコントロールの非癌患者に比べ有意に高値を示したさらに, 切除標本での検討にて, 胃癌組織中でのカテプシン B 含有量は正常組織と比べ有意に高値を示した. 胃癌患者では, 根治手術後には, 血中カテプシン B 値も尿中カテプシン B 排出量もともにコントロール値に回復した. これらの結果は, ライソゾーム酵素であるカテプシン B の癌発育過程での何らかの役割を示唆させるとともに, これらのパラメーターが, 悪性腫瘍の指標となりうることも示唆させた.ja
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisher京都大学医学部外科整形外科学教室内 日本外科宝函編集室ja
dc.subjectLysosomal enzymeen
dc.subjectCathepsin Ben
dc.subjectGastric canceren
dc.subjectライソゾーム酵素ja
dc.subjectカテプシン Bja
dc.subject胃癌ja
dc.subject.ndc494-
dc.title<Original Articles>Serum Cathepsin B Levels, Urinary Excretion of Cathepsin B and Tissue Cathepsin B Content in the Patients with Gastric Canceren
dc.title.alternative<原著>胃癌患者における血中カテプシンB値, 尿中カテプシンB排出量および組織カテプシンB含有量についてja
dc.typedepartmental bulletin paper-
dc.type.niitypeDepartmental Bulletin Paper-
dc.identifier.ncidAN00188295-
dc.identifier.jtitle日本外科宝函ja
dc.identifier.volume62-
dc.identifier.issue5-
dc.identifier.spage217-
dc.identifier.epage221-
dc.textversionpublisher-
dc.sortkey02-
dc.addressDepartment of Surgery, Yoshioka Hospitalen
dc.addressDepartment of Surgery, Yoshioka Hospitalen
dc.address.alternative吉岡病院外科ja
dc.address.alternative吉岡病院外科ja
dc.identifier.pmid8031215-
dcterms.accessRightsopen access-
dc.identifier.pissn0003-9152-
dc.identifier.jtitle-alternativeArchiv für Japanische Chirurgiede
dc.identifier.jtitle-alternativeNihon Geka Hokanen
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