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Title: Holter monitoring for the screening of cardiac disease in diabetes mellitus: The non-invasive Holter monitoring observation of new cardiac events in diabetics study.
Authors: Nakao, Yoko M
Ueshima, Kenji  kyouindb  KAKEN_id
Nohara, Ryuji
Mizunuma, Yoshimi
Segawa, Ikuo
Tanaka-Mizuno, Sachiko
Yasuno, Shinji
Nakao, Kazuwa
Hiramori, Katsuhiko
Kihara, Yasuki
Author's alias: 上嶋, 健治
Keywords: Diabetes mellitus
cardiac disease
silent myocardial ischemia
Holter monitoring
Issue Date: Nov-2015
Publisher: SAGE Publications
Journal title: Diabetes & vascular disease research
Volume: 12
Issue: 6
Start page: 396
End page: 404
Abstract: We investigated the usefulness of Holter monitoring to detect cardiac disease and predict future cardiovascular risk in asymptomatic diabetic patients. This is a multi-centre, prospective study in 406 asymptomatic diabetic patients. They were categorized into three groups based on findings of Holter monitoring. A total of 377 met inclusion criteria and were classified as low (n = 172), moderate (n = 136) and high risk (n = 69). In total, 86 in moderate and 53 in high risk receive further evaluation. In total, 29 in moderate and 25 in high risk were diagnosed as cardiac disease and 12 required additional treatment, including coronary intervention. Over 1.8 years of mean follow-up, 11 (16.5 per 1000 person-years) experienced cardiovascular events. The cumulative incidence in moderate and high risk was higher than that in low risk (p = 0.029 and p = 0.014, respectively). Our study suggests that Holter monitoring may be a useful screening tool to detect cardiac disease and predict future cardiovascular risk in asymptomatic diabetic patients.
Rights: The final, definitive version of this paper has been published in [Diabetes and Vascular Disease Research November 2015 vol. 12 no. 6 396-404] by SAGE Publications Ltd, All rights reserved. © The Author(s)
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/204366
DOI(Published Version): 10.1177/1479164115595523
PubMed ID: 26246490
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