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j.celrep.2016.01.035.pdf5.81 MBAdobe PDF見る/開く
タイトル: 5-Hydroxymethylcytosine Marks Sites of DNA Damage and Promotes Genome Stability.
著者: Kafer, Georgia Rose
Li, Xuan
Horii, Takuro
Suetake, Isao
Tajima, Shoji
Hatada, Izuho
Carlton, Peter Mark
発行日: 16-Feb-2016
出版者: Elsevier Inc.
誌名: Cell reports
巻: 14
号: 6
開始ページ: 1283
終了ページ: 1292
抄録: 5-hydroxymethylcytosine (5hmC) is a DNA base created during active DNA demethylation by the recently discovered TET enzymes. 5hmC has essential roles in gene expression and differentiation. Here, we demonstrate that 5hmC also localizes to sites of DNA damage and repair. 5hmC accumulates at damage foci induced by aphidicolin and microirradiation and colocalizes with major DNA damage response proteins 53BP1 and γH2AX, revealing 5hmC as an epigenetic marker of DNA damage. Deficiency for the TET enzymes eliminates damage-induced 5hmC accumulation and elicits chromosome segregation defects in response to replication stress. Our results indicate that the TET enzymes and 5hmC play essential roles in ensuring genome integrity.
著作権等: © 2016 The Authors. Published by Elsevier Inc.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
URI: http://hdl.handle.net/2433/207261
DOI(出版社版): 10.1016/j.celrep.2016.01.035
PubMed ID: 26854228
出現コレクション:学術雑誌掲載論文等

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