ダウンロード数: 198
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
cpb.c15-00417.pdf | 876.78 kB | Adobe PDF | 見る/開く |
タイトル: | Synthesis of α-Acyloxyketone Derivatives via the Platinum-Catalyzed Migration of Propargylic Esters. |
著者: | Tsukano, Chihiro https://orcid.org/0000-0002-9361-0857 (unconfirmed) Yamamoto, Sho Takemoto, Yoshiji https://orcid.org/0000-0003-1375-3821 (unconfirmed) |
著者名の別形: | 塚野, 千尋 竹本, 佳司 |
キーワード: | platinum propargylic ester migration α-acyloxyketone |
発行日: | 2015 |
出版者: | Pharmaceutical Society of Japan |
誌名: | Chemical & pharmaceutical bulletin |
巻: | 63 |
号: | 9 |
開始ページ: | 710 |
終了ページ: | 719 |
抄録: | The synthesis of α-acyloxyketones via the migration of a propargylic ester followed by the intramolecular nucleophilic addition of the resulting allene was achieved using a cationic platinum catalyst. The optimized conditions for this transformation were determined to be 3 mol% of Pt(cod)Cl[2], 3 mol% of AgNTf[2], and 3 eq of water in toluene at 100 °C, and these conditions were successfully applied to the synthesis of a wide variety of α-aryl-α-acyloxyketones. The mechanism of this reaction was evaluated in detail based on the results of isotope labeling experiments using H[2](18)O. |
著作権等: | © 2015 The Pharmaceutical Society of Japan |
URI: | http://hdl.handle.net/2433/207633 |
DOI(出版社版): | 10.1248/cpb.c15-00417 |
PubMed ID: | 26329864 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。