ダウンロード数: 386
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
eLife.12959.pdf | 2.92 MB | Adobe PDF | 見る/開く |
タイトル: | Neuronal processing of noxious thermal stimuli mediated by dendritic Ca(2+) influx in Drosophila somatosensory neurons. |
著者: | Terada, Shin-Ichiro Matsubara, Daisuke Onodera, Koun Matsuzaki, Masanori Uemura, Tadashi https://orcid.org/0000-0001-7204-3606 (unconfirmed) Usui, Tadao https://orcid.org/0000-0002-0507-1495 (unconfirmed) |
著者名の別形: | 寺田, 晋一郎 松原, 大佑 小野寺, 孝興 上村, 匡 碓井, 理夫 |
発行日: | 15-Feb-2016 |
出版者: | eLife Sciences Publications Ltd. |
誌名: | eLife |
巻: | 5 |
論文番号: | e12959 |
抄録: | Adequate responses to noxious stimuli causing tissue damages are essential for organismal survival. Class IV neurons in Drosophila larvae are polymodal nociceptors responsible for thermal, mechanical, and light sensation. Importantly, activation of Class IV provoked distinct avoidance behaviors, depending on the inputs. We found that noxious thermal stimuli, but not blue light stimulation, caused a unique pattern of Class IV, which were composed of pauses after high-frequency spike trains and a large Ca(2+) rise in the dendrite (the Ca(2+) transient). Both these responses depended on two TRPA channels and the L-type voltage-gated calcium channel (L-VGCC), showing that the thermosensation provokes Ca(2+) influx. The precipitous fluctuation of firing rate in Class IV neurons enhanced the robust heat avoidance. We hypothesize that the Ca(2+) influx can be a key signal encoding a specific modality. |
記述: | 危機回避行動を感覚ニューロンが調節するしくみを解明 -痛覚神経細胞の発火パターンが回避行動を選択している-. 京都大学プレスリリース. 2016-02-24. |
著作権等: | Copyright Terada et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
URI: | http://hdl.handle.net/2433/208998 |
DOI(出版社版): | 10.7554/eLife.12959 |
PubMed ID: | 26880554 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2016-02-24 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。