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Title: Insular gray matter volume and objective quality of life in schizophrenia
Authors: Uwatoko, Teruhisa  kyouindb  KAKEN_id  orcid (unconfirmed)
Yoshizumi, Miho
Miyata, Jun  kyouindb  KAKEN_id
Ubukata, Shiho  kyouindb  KAKEN_id
Fujiwara, Hironobu  kyouindb  KAKEN_id
Kawada, Ryosaku
Kubota, Manabu
Sasamoto, Akihiko
Sugihara, Genichi
Aso, Toshihiko  kyouindb  KAKEN_id  orcid (unconfirmed)
Urayama, Shinichi
Fukuyama, Hidenao
Murai, Toshiya  kyouindb  KAKEN_id
Takahashi, Hidehiko
Author's alias: 高橋, 英彦
Issue Date: 6-Nov-2015
Publisher: Public Library of Science
Journal title: PLOS ONE
Volume: 10
Issue: 11
Thesis number: e0142018
Abstract: Improving quality of life has been recognized as an important outcome for schizophrenia treatment, although the fundamental determinants are not well understood. In this study, we investigated the association between brain structural abnormalities and objective quality of life in schizophrenia patients. Thirty-three schizophrenia patients and 42 age-, sex-, and education-matched healthy participants underwent magnetic resonance imaging. The Quality of Life Scale was used to measure objective quality of life in schizophrenia patients. Voxel-based morphometry was performed to identify regional brain alterations that correlate with Quality of Life Scale score in the patient group. Schizophrenia patients showed gray matter reductions in the frontal, temporal, limbic, and subcortical regions. We then performed voxel-based multiple regression analysis in these regions to identify any correlations between regional gray matter volume and Quality of Life Scale scores. We found that among four subcategories of the scale, the Instrumental Role category score correlated with gray matter volume in the right anterior insula in schizophrenia patients. In addition, this correlation was shown to be mediated by negative symptoms. Our findings suggest that the neural basis of objective quality of life might differ topographically from that of subjective QOL in schizophrenia.
Rights: © 2015 Uwatoko et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI(Published Version): 10.1371/journal.pone.0142018
PubMed ID: 26544607
Appears in Collections:Journal Articles

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