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Title: Mechanical stimulation by postnasal drip evokes cough
Authors: Iwata, Toshiyuki
Ito, Isao  kyouindb  KAKEN_id
Niimi, Akio
Ikegami, Koji
Marumo, Satoshi
Tanabe, Naoya  kyouindb  KAKEN_id
Nakaji, Hitoshi
Kanemitsu, Yoshihiro
Matsumoto, Hisako  kyouindb  KAKEN_id
Kamei, Junzo
Setou, Mitsutoshi
Mishima, Michiaki
Author's alias: 伊藤, 功朗
松本, 久子
三嶋, 理晃
Issue Date: 18-Nov-2015
Publisher: Public Library of Science
Journal title: PLOS ONE
Volume: 10
Issue: 11
Thesis number: e0141823
Abstract: Cough affects all individuals at different times, and its economic burden is substantial. Despite these widespread adverse effects, cough research relies on animal models, which hampers our understanding of the fundamental cause of cough. Postnasal drip is speculated to be one of the most frequent causes of chronic cough; however, this is a matter of debate. Here we show that mechanical stimuli by postnasal drip cause chronic cough. We distinguished human cough from sneezes and expiration reflexes by airflow patterns. Cough and sneeze exhibited one-peak and two-peak patterns, respectively, in expiratory airflow, which were also confirmed by animal models of cough and sneeze. Transgenic mice with ciliary dyskinesia coughed substantially and showed postnasal drip in the pharynx; furthermore, their cough was completely inhibited by nasal airway blockade of postnasal drip. We successfully reproduced cough observed in these mice by injecting artificial postnasal drip in wild-type mice. These results demonstrated that mechanical stimulation by postnasal drip evoked cough. The findings of our study can therefore be used to develop new antitussive drugs that prevent the root cause of cough.
Rights: © 2015 Iwata et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: http://hdl.handle.net/2433/210376
DOI(Published Version): 10.1371/journal.pone.0141823
PubMed ID: 26581078
Appears in Collections:Journal Articles

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