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Title: Coevolutionary dynamics between tribe Cercopithecini tetherins and their lentiviruses
Authors: Takeuchi, Junko S.
Ren, Fengrong
Yoshikawa, Rokusuke
Yamada, Eri
Nakano, Yusuke
Kobayashi, Tomoko
Matsuda, Kenta
Izumi, Taisuke
Misawa, Naoko
Shintaku, Yuta  kyouindb  KAKEN_id
Wetzel, Katherine S.
Collman, Ronald G.
Tanaka, Hiroshi
Hirsch, Vanessa M.
Koyanagi, Yoshio  kyouindb  KAKEN_id
Sato, Kei
Author's alias: 小柳, 義夫
佐藤, 佳
Issue Date: 4-Nov-2015
Publisher: Nature Publishing Group
Journal title: Scientific Reports
Volume: 5
Thesis number: 16021
Abstract: Human immunodeficiency virus, a primate lentivirus (PLV), causes AIDS in humans, whereas most PLVs are less or not pathogenic in monkeys. These notions suggest that the co-evolutionary process of PLVs and their hosts associates with viral pathogenicity, and therefore, that elucidating the history of virus-host co-evolution is one of the most intriguing topics in the field of virology. To address this, recent studies have focused on the interplay between intrinsic anti-viral proteins, such as tetherin, and viral antagonists. Through an experimental-phylogenetic approach, here we investigate the co-evolutionary interplay between tribe Cercopithecini tetherin and viral antagonists, Nef and Vpu. We reveal that tribe Cercopithecini tetherins are positively selected, possibly triggered by ancient Nef-like factor(s). We reconstruct the ancestral sequence of tribe Cercopithecini tetherin and demonstrate that all Nef proteins are capable of antagonizing ancestral Cercopithecini tetherin. Further, we consider the significance of evolutionary arms race between tribe Cercopithecini and their PLVs.
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
DOI(Published Version): 10.1038/srep16021
Appears in Collections:Journal Articles

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