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Title: Pharmacokinetics of chiral dendrimer-triamine-coordinated Gd-MRI contrast agents evaluated by in Vivo MRI and estimated by in Vitro QCM
Authors: Miyake, Yuka
Ishikawa, Syungo
Kimura, Yu  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-5318-9255 (unconfirmed)
Son, Aoi
Imai, Hirohiko  kyouindb  KAKEN_id
Matsuda, Tetsuya
Yamada, Hisatsugu
Toshimitsu, Akio
Kondo, Teruyuki
Author's alias: 木村, 祐
今井, 宏彦
松田, 哲也
近藤, 輝幸
Keywords: chiral dendrimer
gadolinium
contrast agent
magnetic resonance imaging (MRI)
quartz crystal microbalance (QCM)
association constant (Ka)
Issue Date: 18-Dec-2015
Publisher: MDPI
Journal title: Sensors
Volume: 15
Issue: 12
Start page: 31973
End page: 31986
Abstract: Recently, we developed novel chiral dendrimer-triamine-coordinated Gd-MRI contrast agents (Gd-MRI CAs), which showed longitudinal relaxivity (r1) values about four times higher than that of clinically used Gd-DTPA (Magnevist®, Bayer). In our continuing study of pharmacokinetic differences derived from both the chirality and generation of Gd-MRI CAs, we found that the ability of chiral dendrimer Gd-MRI CAs to circulate within the body can be directly evaluated by in vitro MRI (7 T). In this study, the association constants (Ka) of chiral dendrimer Gd-MRI CAs to bovine serum albumin (BSA), measured and calculated with a quartz crystal microbalance (QCM) in vitro, were found to be an extremely easy means for evaluating the body-circulation ability of chiral dendrimer Gd-MRI CAs. The Ka values of S-isomeric dendrimer Gd-MRI CAs were generally greater than those of R-isomeric dendrimer Gd-MRI CAs, which is consistent with the results of our previous MRI study in vivo.
Rights: © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
URI: http://hdl.handle.net/2433/210694
DOI(Published Version): 10.3390/s151229900
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