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Title: Pachychoroid neovasculopathy and age-related macular degeneration.
Authors: Miyake, Masahiro  kyouindb  KAKEN_id
Ooto, Sotaro  kyouindb  KAKEN_id
Yamashiro, Kenji
Takahashi, Ayako  kyouindb  KAKEN_id
Yoshikawa, Munemitsu
Akagi-Kurashige, Yumiko
Ueda-Arakawa, Naoko
Oishi, Akio  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-0977-9458 (unconfirmed)
Nakanishi, Hideo  kyouindb  KAKEN_id
Tamura, Hiroshi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-7740-2732 (unconfirmed)
Tsujikawa, Akitaka  kyouindb  KAKEN_id
Yoshimura, Nagahisa
Author's alias: 大音, 壮太郎
田村, 寛
Issue Date: 6-Nov-2015
Publisher: Nature Publishing Group
Journal title: Scientific reports
Volume: 5
Thesis number: 16204
Abstract: Pachychoroid neovasculopathy is a recently proposed clinical entity of choroidal neovascularization (CNV). As it often masquerades as neovascular age-related macular degeneration (AMD), it is currently controversial whether pachychoroid neovasculopathy should be distinguished from neovascular AMD. This is because its characteristics have yet to be well described. To estimate the relative prevalence of pachychoroid neovasculopathy in comparison with neovascular AMD and to investigate the phenotypic/genetic differences of the two diseases, we evaluated 200 consecutive Japanese patients who agreed to participate in the genetic study and diagnosed with pachychoroid neovasculopathy or neovascular AMD. Pachychoroid neovasculopathy was observed in 39 individuals (19. 5%), which corresponds to one fourth of neovascular AMD. Patients with pachychoroid neovasculopathy were significantly younger (p = 5. 1 × 10[−5]) and showed a greater subfoveal choroidal thickness (p = 3. 4 × 10[−14]). Their genetic susceptibility to AMD was significantly lower than that of neovascular AMD; ARMS2 rs10490924 (p = 0. 029), CFH rs800292 (p = 0. 013) and genetic risk score calculated from 11 AMD susceptibility genes (p = 3.8 × 10[−3]). Current results implicate that the etiologies of the two conditions must be different. Thus, it will be necessary to distinguish these two conditions in future studies
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
URI: http://hdl.handle.net/2433/212497
DOI(Published Version): 10.1038/srep16204
PubMed ID: 26542071
Appears in Collections:Journal Articles

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