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タイトル: | A Genome Scan for Genes Underlying Microgeographic-Scale Local Adaptation in a Wild Arabidopsis Species |
著者: | Kubota, Shosei Iwasaki, Takaya Hanada, Kousuke Nagano, Atsushi J. Fujiyama, Asao Toyoda, Atsushi Sugano, Sumio Suzuki, Yutaka Hikosaka, Kouki Ito, Motomi Morinaga, Shin Ichi |
著者名の別形: | 永野, 惇 |
発行日: | 14-Jul-2015 |
出版者: | Public Library of Science |
誌名: | PLOS Genetics |
巻: | 11 |
号: | 7 |
論文番号: | e1005361 |
抄録: | Adaptive divergence at the microgeographic scale has been generally disregarded because high gene flow is expected to disrupt local adaptation. Yet, growing number of studies reporting adaptive divergence at a small spatial scale highlight the importance of this process in evolutionary biology. To investigate the genetic basis of microgeographic local adaptation, we conducted a genome-wide scan among sets of continuously distributed populations of Arabidopsis halleri subsp. gemmifera that show altitudinal phenotypic divergence despite gene flow. Genomic comparisons were independently conducted in two distinct mountains where similar highland ecotypes are observed, presumably as a result of convergent evolution. Here, we established a de novo reference genome and employed an individual-based resequencing for a total of 56 individuals. Among 527, 225 reliable SNP loci, we focused on those showing a unidirectional allele frequency shift across altitudes. Statistical tests on the screened genes showed that our microgeographic population genomic approach successfully retrieve genes with functional annotations that are in line with the known phenotypic and environmental differences between altitudes. Furthermore, comparison between the two distinct mountains enabled us to screen out those genes that are neutral or adaptive only in either mountain, and identify the genes involved in the convergent evolution. Our study demonstrates that the genomic comparison among a set of genetically connected populations, instead of the commonly-performed comparison between two isolated populations, can also offer an effective screening for the genetic basis of local adaptation. |
著作権等: | © 2015 Kubota et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
URI: | http://hdl.handle.net/2433/214321 |
DOI(出版社版): | 10.1371/journal.pgen.1005361 |
PubMed ID: | 26172569 |
出現コレクション: | 学術雑誌掲載論文等 |
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