ダウンロード数: 122
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
journal.ppat.1005247.pdf | 2.3 MB | Adobe PDF | 見る/開く |
タイトル: | Broadening of Virus-Specific CD8+ T-Cell Responses Is Indicative of Residual Viral Replication in Aviremic SIV Controllers |
著者: | Nomura, Takushi Yamamoto, Hiroyuki Ishii, Hiroshi Akari, Hirofumi https://orcid.org/0000-0003-2166-6015 (unconfirmed) Naruse, Taeko K. Kimura, Akinori Matano, Tetsuro |
著者名の別形: | 明里, 宏文 |
発行日: | 4-Nov-2015 |
出版者: | Public Library of Science |
誌名: | PLOS Pathogens |
巻: | 11 |
号: | 11 |
論文番号: | e1005247 |
抄録: | Control of HIV replication is a rare immunological event, providing clues to understand the viral control mechanism. CD8+ T-cell responses are crucial for virus control, but it is unclear whether lasting HIV containment can be achieved after establishment of infection. Here, we describe lasting SIV containment in a macaque AIDS model. Analysis of ten rhesus macaques that controlled viremia for 2 years post-infection found accumulation of proviral gag and nef CD8+ T-cell escape mutations in four of them. These four controllers mounted CD8+ T cells targeting Gag, Nef, and other viral proteins at 4 months, suggesting that broadening of CD8+ T-cell targets can be an indicator of the beginning of viral control failure. The remaining six aviremic SIV controllers, however, harbored proviruses without mutations and showed no or little broadening of their CD8+ T-cell responses in the chronic phase. Indeed, three of the latter six exhibiting no change in CD8+ T-cell targets showed gradual decreases in SIV-specific CD8+ T-cell frequencies, implying a concomitant reduction in viral replication. Thus, stability of the breadth of virus-specific CD8+ T-cell responses may represent a status of lasting HIV containment by CD8+ T cells. |
著作権等: | © 2015 Nomura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
URI: | http://hdl.handle.net/2433/214495 |
DOI(出版社版): | 10.1371/journal.ppat.1005247 |
PubMed ID: | 26536034 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。