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タイトル: | Fish oil accelerates diet-induced entrainment of the mouse peripheral clock via GPR120 |
著者: | Furutani, Akiko Ikeda, Yuko Itokawa, Misa Nagahama, Hiroki Ohtsu, Teiji Furutani, Naoki Kamagata, Mayo Yang, Zhi Hong Hirasawa, Akira https://orcid.org/0000-0001-5692-805X (unconfirmed) Tahara, Yu Shibata, Shigenobu |
著者名の別形: | 平澤, 明 |
発行日: | 10-Jul-2015 |
出版者: | Public Library of Science |
誌名: | PLOS ONE |
巻: | 10 |
号: | 7 |
論文番号: | e0132472 |
抄録: | The circadian peripheral clock is entrained by restricted feeding (RF) at a fixed time of day, and insulin secretion regulates RF-induced entrainment of the peripheral clock in mice. Thus, carbohydrate-rich food may be ideal for facilitating RF-induced entrainment, although the role of dietary oils in insulin secretion and RF-induced entrainment has not been described. The soybean oil component of standard mouse chow was substituted with fish or soybean oil containing docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA). Tuna oil (high DHA/EPA), menhaden oil (standard), and DHA/EPA dissolved in soybean oil increased insulin secretion and facilitated RF-induced phase shifts of the liver clock as represented by the bioluminescence rhythms of PER2::LUCIFERASE knock-in mice. In this model, insulin depletion blocked the effect of tuna oil and fish oil had no effect on mice deficient for GPR120, a polyunsaturated fatty acid receptor. These results suggest food containing fish oil or DHA/EPA is ideal for adjusting the peripheral clock. |
著作権等: | © 2015 Furutani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited |
URI: | http://hdl.handle.net/2433/214515 |
DOI(出版社版): | 10.1371/journal.pone.0132472 |
PubMed ID: | 26161796 |
出現コレクション: | 学術雑誌掲載論文等 |
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