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タイトル: Fish oil accelerates diet-induced entrainment of the mouse peripheral clock via GPR120
著者: Furutani, Akiko
Ikeda, Yuko
Itokawa, Misa
Nagahama, Hiroki
Ohtsu, Teiji
Furutani, Naoki
Kamagata, Mayo
Yang, Zhi Hong
Hirasawa, Akira  kyouindb  KAKEN_id
Tahara, Yu
Shibata, Shigenobu
著者名の別形: 平澤, 明
発行日: 10-Jul-2015
出版者: Public Library of Science
誌名: PLOS ONE
巻: 10
号: 7
論文番号: e0132472
抄録: The circadian peripheral clock is entrained by restricted feeding (RF) at a fixed time of day, and insulin secretion regulates RF-induced entrainment of the peripheral clock in mice. Thus, carbohydrate-rich food may be ideal for facilitating RF-induced entrainment, although the role of dietary oils in insulin secretion and RF-induced entrainment has not been described. The soybean oil component of standard mouse chow was substituted with fish or soybean oil containing docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA). Tuna oil (high DHA/EPA), menhaden oil (standard), and DHA/EPA dissolved in soybean oil increased insulin secretion and facilitated RF-induced phase shifts of the liver clock as represented by the bioluminescence rhythms of PER2::LUCIFERASE knock-in mice. In this model, insulin depletion blocked the effect of tuna oil and fish oil had no effect on mice deficient for GPR120, a polyunsaturated fatty acid receptor. These results suggest food containing fish oil or DHA/EPA is ideal for adjusting the peripheral clock.
著作権等: © 2015 Furutani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
URI: http://hdl.handle.net/2433/214515
DOI(出版社版): 10.1371/journal.pone.0132472
PubMed ID: 26161796
出現コレクション:学術雑誌掲載論文等

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