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Title: Association of cerebral white matter lesions with cognitive function and mood in Japanese elderly people: a population-based study.
Authors: Yamawaki, Mika
Wada-Isoe, Kenji
Yamamoto, Mikie
Nakashita, Satoko
Uemura, Yusuke
Takahashi, Yoshimitsu  kyouindb  KAKEN_id
Nakayama, Takeo  kyouindb  KAKEN_id
Nakashima, Kenji
Author's alias: 高橋, 由光
Keywords: Cognitive function
deep white matter hyperintensities
periventricular hyperintensities
population based
Issue Date: Mar-2015
Publisher: Wiley Periodicals, Inc.
Journal title: Brain and behavior
Volume: 5
Issue: 3
Thesis number: e00315
Abstract: [Background] To determine the relationships between regional white matter lesions (WMLs), lifestyle factors, and cognitive, motor function and mood. [Methods] A comprehensive evaluation, including brain MRI, blood tests, the Unified Parkinson's Disease Rating Scale, the Mini Mental State Examination, and the Geriatric Depression Scale, was performed for people aged 65 years or older living in Ama-cho on October 1, 2009. Participants were classified by severity of periventricular hyperintensities (PVH) and deep white matter hyperintensities (DWMH) using the Fazekas score. [Results] Of 900 eligible participants, 688 (76.4%) were enrolled, including 303 men. Significant predictors of severe PVH were older age, lower low-density lipoprotein cholesterol (LDL-C) levels, elevated blood pressure (BP), cerebral infarction, and no current alcohol use. Significant predictors of severe DWMH were older age, lower 1, 5-anhydroglucitol (1, 5-AG) levels, elevated BP, cerebral infarction, and no current alcohol use. Higher cognitive function was associated with younger age, female sex, mild DWMH, more years of education, and higher high-density lipoprotein cholesterol levels. Depressive symptoms were associated with lower 1, 5-AG levels, lower LDL-C levels, moderate to severe PVH, and no current alcohol use. [Conclusions] White matter lesions in elderly people were related to hypertension and impaired glucose tolerance. The severity of WMLs was associated with cognitive function and mood.
Rights: © 2015 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
DOI(Published Version): 10.1002/brb3.315
PubMed ID: 25798332
Appears in Collections:Journal Articles

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