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Title: Non-autonomous overgrowth by oncogenic niche cells: Cellular cooperation and competition in tumorigenesis
Authors: Enomoto, Masato  kyouindb  KAKEN_id
Vaughen, John
Igaki, Tatsushi  kyouindb  KAKEN_id
Author's alias: 井垣, 達吏
Keywords: Cell competition
Cell death
Cellular cooperation
Cellular senescence
Tumor progression
Issue Date: Dec-2015
Publisher: Blackwell Publishing Ltd
Journal title: Cancer Science
Volume: 106
Issue: 12
Start page: 1651
End page: 1658
Abstract: Tumor progression is classically viewed as the Darwinian evolution of subclones that sequentially acquire genetic mutations and autonomously overproliferate. However, growing evidence suggests that tumor microenvironment and subclone heterogeneity contribute to non-autonomous tumor progression. Recent Drosophila studies revealed a common mechanism by which clones of genetically altered cells trigger non-autonomous overgrowth. Such "oncogenic niche cells" (ONCs) do not overgrow but instead stimulate neighbor overgrowth and metastasis. Establishment of ONCs depends on competition and cooperation between heterogeneous cell populations. This review characterizes diverse ONCs identified in Drosophila and describes the genetic basis of non-autonomous tumor progression. Similar mechanisms may contribute to mammalian cancer progression and recurrence.
Rights: © 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
URI: http://hdl.handle.net/2433/215151
DOI(Published Version): 10.1111/cas.12816
PubMed ID: 26362609
Appears in Collections:Journal Articles

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