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dc.contributor.authorMatsumura, Shigeruja
dc.contributor.authorKojidani, Tomokoja
dc.contributor.authorKamioka, Yujija
dc.contributor.authorUchida, Seiichija
dc.contributor.authorHaraguchi, Tokukoja
dc.contributor.authorKimura, Akatsukija
dc.contributor.authorToyoshima, Fumikoja
dc.contributor.alternative松村, 繁ja
dc.contributor.alternative豊島, 文子ja
dc.description.abstractDespite theoretical and physical studies implying that cell-extracellular matrix adhesion geometry governs the orientation of the cell division axis, the molecular mechanisms that translate interphase adhesion geometry to the mitotic spindle orientation remain elusive. Here, we show that the cellular edge retraction during mitotic cell rounding correlates with the spindle axis. At the onset of mitotic cell rounding, caveolin-1 is targeted to the retracting cortical region at the proximal end of retraction fibres, where ganglioside GM1-enriched membrane domains with clusters of caveola-like structures are formed in an integrin and RhoA-dependent manner. Furthermore, Gαi1-LGN-NuMA, a well-known regulatory complex of spindle orientation, is targeted to the caveolin-1-enriched cortical region to guide the spindle axis towards the cellular edge retraction. We propose that retraction-induced cortical heterogeneity of caveolin-1 during mitotic cell rounding sets the spindle orientation in the context of adhesion geometry.ja
dc.publisherNature Publishing Groupja
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
dc.subjectBiological sciencesja
dc.subjectCell biologyja
dc.titleInterphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1ja
dc.type.niitypeJournal Articleja
dc.identifier.jtitleNature Communicationsja
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