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Title: Association between retinal hemorrhagic pattern and macular perfusion status in eyes with acute branch retinal vein occlusion.
Authors: Muraoka, Yuki  kyouindb  KAKEN_id
Uji, Akihito  kyouindb  KAKEN_id
Tsujikawa, Akitaka  kyouindb  KAKEN_id
Murakami, Tomoaki  kyouindb  KAKEN_id
Ooto, Sotaro
Suzuma, Kiyoshi
Takahashi, Ayako  kyouindb  KAKEN_id
Iida, Yuto
Miwa, Yuko
Hata, Masayuki  kyouindb  KAKEN_id
Yoshimura, Nagahisa
Author's alias: 村岡 勇貴
宇治, 彰人
村上, 智昭
大音, 壮太郎
鈴間, 潔
畑, 匡侑
吉村, 長久
Issue Date: 23-Jun-2016
Publisher: Springer Nature
Journal title: Scientific reports
Volume: 6
Thesis number: 28554
Abstract: This prospective study included 63 eyes with acute branch retinal vein occlusion (BRVO) to evaluate the retinal hemorrhagic patterns at the posterior poles and explore their clinical relevance in macular perfusion differentiation. Retinal hemorrhagic patterns and macular perfusion status were evaluated via fundus photography and fluorescein angiography, respectively. Macular perfusion was judged as nonischemic in 30, ischemic in 28, and undeterminable in 5 among the 63 eyes. Predominant hemorrhagic patterns were flame-shaped in 39 (67. 2%) and non-flame-shaped in 19 (32. 8%) eyes. All 39 eyes with a flame-shaped hemorrhage showed a nonischemic macula. Of the 19 eyes classified as having a non-flame-shaped hemorrhage, 13 (68. 4%) had an ischemic macula and 6 (31. 6%) had a nonischemic macula (P<0. 001). Parallelism in eyes with a flame-shaped hemorrhage was higher than in those with a non-flame-shaped hemorrhage (P<0. 001), and in those with a nonischemic macula versus those with an ischemic macula (P<0. 001). The area under the curve for parallelism was 0. 975 (P<0. 001), suggesting an accurate diagnostic parameter for macular perfusion differentiation. In conclusion, we objectively evaluated retinal hemorrhagic patterns at the posterior pole in BRVO using the parallelism method, which was useful in differentiating macular perfusion status.
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit
DOI(Published Version): 10.1038/srep28554
PubMed ID: 27334338
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