ダウンロード数: 157
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
s12931-015-0280-9.pdf | 939.1 kB | Adobe PDF | 見る/開く |
タイトル: | Matrix metalloproteinase-10: A novel biomarker for idiopathic pulmonary fibrosis |
著者: | Sokai, Akihiko Handa, Tomohiro Tanizawa, Kiminobu https://orcid.org/0000-0002-5719-0744 (unconfirmed) Oga, Toru Uno, Kazuko Tsuruyama, Tatsuaki Kubo, Takeshi Ikezoe, Kohei https://orcid.org/0000-0003-1097-2084 (unconfirmed) Nakatsuka, Yoshinari Tanimura, Kazuya Muro, Shigeo Hirai, Toyohiro Nagai, Sonoko Chin, Kazuo Mishima, Michiaki |
著者名の別形: | 半田, 知宏 谷澤, 公伸 小賀, 徹 鶴山, 竜昭 久保, 武 室, 繁郎 平井, 豊博 陳, 和夫 三嶋, 理晃 |
キーワード: | Matrix metalloproteinase-10 Idiopathic pulmonary fibrosis Biomarker |
発行日: | 29-Sep-2015 |
出版者: | BioMed Central Ltd. |
誌名: | Respiratory Research |
巻: | 16 |
論文番号: | 120 |
抄録: | Background: Matrix metalloproteinases (MMPs) are believed to be involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF), and MMP-7 has been described as a useful biomarker for IPF. However, little is known regarding the significance of MMP-10 as a biomarker for IPF. Methods: This observational cohort study included 57 patients with IPF. Serum MMPs were comprehensively measured in all patients, and the relationships between these markers and both disease severity and prognosis were evaluated. Bronchoalveolar lavage fluid (BALF) MMP-7 and -10 levels were measured in 19 patients to investigate the correlation between these markers and their corresponding serum values. Immunohistochemical staining for MMP-10 was also performed in IPF lung tissue. Results: Serum MMP-7 and -10 levels correlated significantly with both the percentage of predicted forced vital capacity (ρ = -0.31, p = 0.02 and ρ = -0.34, p < 0.01, respectively) and the percentage of predicted diffusing capacity of the lung for carbon monoxide (ρ = -0.32, p = 0.02 and ρ = -0.43, p < 0.01, respectively). BALF MMP-7 and -10 levels correlated with their corresponding serum concentrations. Only serum MMP-10 predicted clinical deterioration within 6 months and overall survival. In IPF lungs, the expression of MMP-10 was enhanced and localized to the alveolar epithelial cells, macrophages, and peripheral bronchiolar epithelial cells. Conclusions: MMP-10 may be a novel biomarker reflecting both disease severity and prognosis in patients with IPF. |
著作権等: | © 2015 Sokai et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
URI: | http://hdl.handle.net/2433/215849 |
DOI(出版社版): | 10.1186/s12931-015-0280-9 |
PubMed ID: | 26415518 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。