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Title: Matrix metalloproteinase-10: A novel biomarker for idiopathic pulmonary fibrosis
Authors: Sokai, Akihiko
Handa, Tomohiro  kyouindb  KAKEN_id
Tanizawa, Kiminobu  kyouindb  KAKEN_id
Oga, Toru
Uno, Kazuko
Tsuruyama, Tatsuaki  kyouindb  KAKEN_id
Kubo, Takeshi  kyouindb  KAKEN_id
Ikezoe, Kohei
Nakatsuka, Yoshinari
Tanimura, Kazuya
Muro, Shigeo  kyouindb  KAKEN_id
Hirai, Toyohiro  kyouindb  KAKEN_id
Nagai, Sonoko
Chin, Kazuo
Mishima, Michiaki
Author's alias: 半田, 知宏
谷澤, 公伸
小賀, 徹
鶴山, 竜昭
久保, 武
室, 繁郎
平井, 豊博
陳, 和夫
三嶋, 理晃
Keywords: Matrix metalloproteinase-10
Idiopathic pulmonary fibrosis
Issue Date: 29-Sep-2015
Publisher: BioMed Central Ltd.
Journal title: Respiratory Research
Volume: 16
Thesis number: 120
Abstract: Background: Matrix metalloproteinases (MMPs) are believed to be involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF), and MMP-7 has been described as a useful biomarker for IPF. However, little is known regarding the significance of MMP-10 as a biomarker for IPF. Methods: This observational cohort study included 57 patients with IPF. Serum MMPs were comprehensively measured in all patients, and the relationships between these markers and both disease severity and prognosis were evaluated. Bronchoalveolar lavage fluid (BALF) MMP-7 and -10 levels were measured in 19 patients to investigate the correlation between these markers and their corresponding serum values. Immunohistochemical staining for MMP-10 was also performed in IPF lung tissue. Results: Serum MMP-7 and -10 levels correlated significantly with both the percentage of predicted forced vital capacity (ρ = -0.31, p = 0.02 and ρ = -0.34, p < 0.01, respectively) and the percentage of predicted diffusing capacity of the lung for carbon monoxide (ρ = -0.32, p = 0.02 and ρ = -0.43, p < 0.01, respectively). BALF MMP-7 and -10 levels correlated with their corresponding serum concentrations. Only serum MMP-10 predicted clinical deterioration within 6 months and overall survival. In IPF lungs, the expression of MMP-10 was enhanced and localized to the alveolar epithelial cells, macrophages, and peripheral bronchiolar epithelial cells. Conclusions: MMP-10 may be a novel biomarker reflecting both disease severity and prognosis in patients with IPF.
Rights: © 2015 Sokai et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
DOI(Published Version): 10.1186/s12931-015-0280-9
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