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Title: Transcranial direct current stimulation over the primary and secondary somatosensory cortices transiently improves tactile spatial discrimination in stroke patients
Authors: Fujimoto, Shuhei
Kon, Noriko
Otaka, Yohei
Yamaguchi, Tomofumi
Nakayama, Takeo  kyouindb  KAKEN_id
Kondo, Kunitsugu
Ragert, Patrick
Tanaka, Satoshi
Author's alias: 藤本, 修平
Keywords: cortical plasticity
inter-hemispheric inhibition (IHI)
grating orientation
transcranial direct current stimulation (tDCS)
transcranial magnetic stimulation (TMS)
Issue Date: 31-Mar-2016
Publisher: Frontiers Research Foundation
Journal title: Frontiers in Neuroscience
Volume: 10
Thesis number: 128
Abstract: In healthy subjects, dual hemisphere transcranial direct current stimulation (tDCS) over the primary (S1) and secondary somatosensory cortices (S2) has been found to transiently enhance tactile performance. However, the effect of dual hemisphere tDCS on tactile performance in stroke patients with sensory deficits remains unknown. The purpose of this study was to investigate whether dual hemisphere tDCS over S1 and S2 could enhance tactile discrimination in stroke patients. We employed a double-blind, crossover, sham-controlled experimental design. Eight chronic stroke patients with sensory deficits participated in this study. We used a grating orientation task (GOT) to measure the tactile discriminative threshold of the affected and non-affected index fingers before, during, and 10 min after four tDCS conditions. For both the S1 and S2 conditions, we placed an anodal electrode over the lesioned hemisphere and a cathodal electrode over the opposite hemisphere. We applied tDCS at an intensity of 2 mA for 15 min in both S1 and S2 conditions. We included two sham conditions in which the positions of the electrodes and the current intensity were identical to that in the S1 and S2 conditions except that current was delivered for the initial 15 s only. We found that GOT thresholds for the affected index finger during and 10 min after the S1 and S2 conditions were significantly lower compared with each sham condition. GOT thresholds were not significantly different between the S1 and S2 conditions at any time point. We concluded that dual-hemisphere tDCS over S1 and S2 can transiently enhance tactile discriminative task performance in chronic stroke patients with sensory dysfunction.
Rights: © 2016 Fujimoto, Kon, Otaka, Yamaguchi, Nakayama, Kondo, Ragert and Tanaka. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI(Published Version): 10.3389/fnins.2016.00128
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