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タイトル: | The Effect of the Molecular Architecture on the Antioxidant Properties of Chitosan Gallate |
著者: | Wu, Chunhua Wang, Liping Fang, Zhongxiang Hu, Yaqin Chen, Shiguo Sugawara, Tatsuya ![]() ![]() ![]() Ye, Xingqian |
著者名の別形: | 菅原, 達也 |
キーワード: | chitosan gallate molecular architecture antioxidant activity grafting gallic acid |
発行日: | 13-May-2016 |
出版者: | MDPI AG |
誌名: | Marine drugs |
巻: | 14 |
号: | 5 |
論文番号: | 95 |
抄録: | To elucidate the structure–antioxidant activity relationships of chitosan gallate (CG), a series of CG derivatives with different degrees of substitution (DS’s) and molecular weights (MWs) were synthesized from chitosan (CS) and gallic acid (GA) via a free radical graft reaction. A higher MW led to a lower DS of CG. The structures of CG were characterized by FT-IR and 1H NMR, and results showed that GA was mainly conjugated to the C-2 and C-6 positions of the CS chain. The antioxidant activity (the DPPH radical scavenging activity and reducing power) were enhanced with an increased DS and a decreased MW of CG. A correlation between antioxidant activities and the DS and MW of CG was also established. In addition, a suitable concentration (0~250 μg/mL) of CG with different MWs (32.78~489.32 kDa) and DS’s (0~92.89 mg·GAE/g CG) has no cytotoxicity. These results should provide a guideline to the application of CG derivatives in food or pharmacology industries. |
著作権等: | This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
URI: | http://hdl.handle.net/2433/216060 |
DOI(出版社版): | 10.3390/md14050095 |
PubMed ID: | 27187421 |
出現コレクション: | 学術雑誌掲載論文等 |
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