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Title: Heterogeneous fibroblasts underlie age-dependent tertiary lymphoid tissues in the kidney
Authors: Sato, Yuki  kyouindb  KAKEN_id
Mii, Akiko
Hamazaki, Yoko  kyouindb  KAKEN_id
Fujita, Harumi
Nakata, Hirosuke
Masuda, Kyoko  kyouindb  KAKEN_id
Nishiyama, Shingo
Shibuya, Shinsuke
Haga, Hironori  kyouindb  KAKEN_id
Ogawa, Osamu
Shimizu, Akira  kyouindb  KAKEN_id
Narumiya, Shuh
Kaisho, Tsuneyasu
Arita, Makoto
Yanagisawa, Masashi
Miyasaka, Masayuki
Sharma, Kumar
Minato, Nagahiro
Kawamoto, Hiroshi  kyouindb  KAKEN_id  orcid (unconfirmed)
Yanagita, Motoko  kyouindb  KAKEN_id
Author's alias: 佐藤, 有紀
柳田, 素子
Issue Date: 21-Jul-2016
Publisher: American Society for Clinical Investigation
Journal title: JCI Insight
Volume: 1
Issue: 11
Thesis number: e87680
Abstract: Acute kidney injury (AKI) is a common clinical condition defined as a rapid decline in kidney function. AKI is a global health burden, estimated to cause 2 million deaths annually worldwide. Unlike AKI in the young, which is reversible, AKI in the elderly often leads to end-stage renal disease, and the mechanism that prevents kidney repair in the elderly is unclear. Here we demonstrate that aged but not young mice developed multiple tertiary lymphoid tissues (TLTs) in the kidney after AKI. TLT size was associated with impaired renal function and increased expression of proinflammatory cytokines and homeostatic chemokines, indicating a possible contribution of TLTs to sustained inflammation after injury. Notably, resident fibroblasts from a single lineage diversified into p75 neurotrophin receptor[+] (p75NTR[+]) fibroblasts and homeostatic chemokine–producing fibroblasts inside TLTs, and retinoic acid–producing fibroblasts around TLTs. Deletion of CD4[+] cells as well as late administration of dexamethasone abolished TLTs and improved renal outcomes. Importantly, aged but not young human kidneys also formed TLTs that had cellular and molecular components similar to those of mouse TLTs. Therefore, the inhibition of TLT formation may offer a novel therapeutic strategy for AKI in the elderly.
Description: 高齢者腎臓病の新たな病態メカニズムの発見・新規治療戦略の可能性を拓く. 京都大学プレスリリース. 2016-07-22.
Rights: Some articles published in JCI Insight use the Creative Commons Attribution 4.0 International License (CC-BY 4.0). Articles using this license are clearly marked. Readers wishing to reproduce content from such articles should follow the guidelines of the CC-BY 4.0 license.
DOI(Published Version): 10.1172/jci.insight.87680
PubMed ID: 27699223
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