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Title: | An RNA-dependent RNA polymerase gene in bat genomes derived from an ancient negative-strand RNA virus. |
Authors: | Horie, Masayuki ![]() ![]() Kobayashi, Yuki Honda, Tomoyuki Fujino, Kan Akasaka, Takumi Kohl, Claudia Wibbelt, Gudrun Mühldorfer, Kristin Kurth, Andreas Müller, Marcel A. Corman, Victor M. Gillich, Nadine Suzuki, Yoshiyuki Schwemmle, Martin Tomonaga, Keizo ![]() ![]() ![]() |
Author's alias: | 朝長, 啓造 |
Issue Date: | 13-May-2016 |
Publisher: | Springer Nature |
Journal title: | Scientific reports |
Volume: | 6 |
Thesis number: | 25873 |
Abstract: | Endogenous bornavirus-like L (EBLL) elements are inheritable sequences derived from ancient bornavirus L genes that encode a viral RNA-dependent RNA polymerase (RdRp) in many eukaryotic genomes. Here, we demonstrate that bats of the genus Eptesicus have preserved for more than 11. 8 million years an EBLL element named eEBLL-1, which has an intact open reading frame of 1, 718 codons. The eEBLL-1 coding sequence revealed that functional motifs essential for mononegaviral RdRp activity are well conserved in the EBLL-1 genes. Genetic analyses showed that natural selection operated on eEBLL-1 during the evolution of Eptesicus. Notably, we detected efficient transcription of eEBLL-1 in tissues from Eptesicus bats. To the best of our knowledge, this study is the first report showing that the eukaryotic genome has gained a riboviral polymerase gene from an ancient virus that has the potential to encode a functional RdRp. |
Rights: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
URI: | http://hdl.handle.net/2433/216228 |
DOI(Published Version): | 10.1038/srep25873 |
PubMed ID: | 27174689 |
Appears in Collections: | Journal Articles |

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