|Title:||An RNA-dependent RNA polymerase gene in bat genomes derived from an ancient negative-strand RNA virus.|
|Authors:||Horie, Masayuki https://orcid.org/0000-0003-4682-7698 (unconfirmed)|
Müller, Marcel A.
Corman, Victor M.
|Author's alias:||朝長, 啓造|
|Journal title:||Scientific reports|
|Abstract:||Endogenous bornavirus-like L (EBLL) elements are inheritable sequences derived from ancient bornavirus L genes that encode a viral RNA-dependent RNA polymerase (RdRp) in many eukaryotic genomes. Here, we demonstrate that bats of the genus Eptesicus have preserved for more than 11. 8 million years an EBLL element named eEBLL-1, which has an intact open reading frame of 1, 718 codons. The eEBLL-1 coding sequence revealed that functional motifs essential for mononegaviral RdRp activity are well conserved in the EBLL-1 genes. Genetic analyses showed that natural selection operated on eEBLL-1 during the evolution of Eptesicus. Notably, we detected efficient transcription of eEBLL-1 in tissues from Eptesicus bats. To the best of our knowledge, this study is the first report showing that the eukaryotic genome has gained a riboviral polymerase gene from an ancient virus that has the potential to encode a functional RdRp.|
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|Appears in Collections:||Journal Articles|
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