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Title: Twenty four-hour exposure to a 0.12 THz electromagnetic field does not affect the genotoxicity, morphological changes, or expression of heat shock protein in HCE-T cells
Authors: Koyama, Shin  kyouindb  KAKEN_id
Narita, Eijiro
Shimizu, Yoko
Shiina, Takeo
Taki, Masao
Shinohara, Naoki  kyouindb  KAKEN_id
Miyakoshi, Junji  kyouindb  KAKEN_id
Author's alias: 小山, 眞
成田, 英二郎
藤原, 真毅
宮越, 順二
Keywords: terahertz (THz)
cellular genotoxicity
micronucleus (MN) formation
morphological changes
heat shock protein (Hsp)
long-term exposure
human eye cells
Issue Date: 5-Aug-2016
Publisher: MDPI AG
Journal title: International Journal of Environmental Research and Public Health
Volume: 13
Issue: 8
Thesis number: 793
Abstract: To investigate the cellular effects of terahertz (THz) exposure, human corneal epithelial (HCE-T) cells derived from human eye were exposed to 0.12 THz radiation at 5 mW/cm2 for 24 h, then the genotoxicity, morphological changes, and heat shock protein (Hsp) expression of the cells were examined. There was no statistically significant increase in the micronucleus (MN) frequency of cells exposed to 0.12 THz radiation compared with sham-exposed controls and incubator controls, whereas the MN frequency of cells treated with bleomycin for 1 h (positive control) did increase significantly. Similarly, there were no significant morphological changes in cells exposed to 0.12 THz radiation compared to sham-exposed controls and incubator controls, and Hsp expression (Hsp27, Hsp70, and Hsp90α) was also not significantly different between the three treatments. These results indicate that exposure to 0.12 THz radiation using the present conditions appears to have no or very little effect onMN formation, morphological changes, and Hsp expression in cells derived from human eye.
Rights: © 2016 by the authors; licensee MDPI, Basel, Switzerland.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 4.0).
URI: http://hdl.handle.net/2433/216505
DOI(Published Version): 10.3390/ijerph13080793
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