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Title: Expression of Tim-1 in primary CNS lymphoma
Authors: Kishimoto, Wataru
Nishikori, Momoko  kyouindb  KAKEN_id
Arima, Hiroshi
Miyoshi, Hiroaki
Sasaki, Yuya
Kitawaki, Toshio  kyouindb  KAKEN_id
Shirakawa, Kotaro  kyouindb  KAKEN_id
Kato, Takeharu
Imaizumi, Yoshitaka
Ishikawa, Takayuki
Ohno, Hitoshi
Haga, Hironori  kyouindb  KAKEN_id
Ohshima, Koichi
Takaori-Kondo, Akifumi
Author's alias: 錦織, 桃子
北脇, 年雄
羽賀, 博典
Keywords: Biomarker
Central nervous system
Diffuse large B-cell lymphoma
Immunohistochemistry
Tim-1
Issue Date: 5-Oct-2016
Publisher: Wiley-Blackwell
Journal title: Cancer Medicine
Volume: 5
Issue: 11
Start page: 3235
End page: 3245
Abstract: Primary central nervous system lymphoma (PCNSL) is a distinct subtype of extranodal lymphoma with aggressive clinical course and poor outcome. As increased IL-10/IL-6 ratio is recognized in the cerebrospinal fluid (CSF) of PCNSL patients, we hypothesized that PCNSL might originate from a population of B cells with high IL-10-producing capacity, an equivalent of "regulatory B cells" in mice. We intended in this study to clarify whether Tim-1, a molecule known as a marker for regulatory B cells in mice, is expressed in PCNSL. By immunohistochemical analysis, Tim-1 was shown to be positive in as high as 54.2% of PCNSL (26 of 58 samples), while it was positive in 19.1% of systemic diffuse large B-cell lymphoma (DLBCL) samples (17 of 89 samples; P < 0.001). Tim-1 expression positively correlated with IL-10 expression in PCNSL (Cramer's V = 0.55, P < 0.001), and forced expression of Tim-1 in a PCNSL cell line resulted in increased IL-10 secretion, suggesting that Tim-1 is functionally linked with IL-10 production in PCNSL. Moreover, soluble Tim-1 was detectable in the CSF of PCNSL patients, and was suggested to parallel disease activity. In summary, PCNSL is characterized by frequent Tim-1 expression, and its soluble form in CSF may become a useful biomarker for PCNSL.
Rights: © 2016 Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2433/217325
DOI(Published Version): 10.1002/cam4.930
PubMed ID: 27709813
Appears in Collections:Journal Articles

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