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ファイル | 記述 | サイズ | フォーマット | |
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j.neuron.2015.12.025.pdf | 8.69 MB | Adobe PDF | 見る/開く |
タイトル: | A Primary Role for Nucleus Accumbens and Related Limbic Network in Vocal Tics |
著者: | McCairn, Kevin W. Nagai, Yuji Hori, Yukiko Ninomiya, Taihei Kikuchi, Erika Lee, Ju-Young Suhara, Tetsuya Iriki, Atsushi Minamimoto, Takafumi Takada, Masahiko https://orcid.org/0000-0003-0774-2333 (unconfirmed) Isoda, Masaki Matsumoto, Masayuki |
著者名の別形: | 髙田, 昌彦 |
発行日: | 20-Jan-2016 |
出版者: | Elsevier BV |
誌名: | Neuron |
巻: | 89 |
号: | 2 |
開始ページ: | 300 |
終了ページ: | 307 |
抄録: | Inappropriate vocal expressions, e.g., vocal tics in Tourette syndrome, severely impact quality of life. Neural mechanisms underlying vocal tics remain unexplored because no established animal model representing the condition exists. We report that unilateral disinhibition of the nucleus accumbens (NAc) generates vocal tics in monkeys. Whole-brain PET imaging identified prominent, bilateral limbic cortico-subcortical activation. Local field potentials (LFPs) developed abnormal spikes in the NAc and the anterior cingulate cortex (ACC). Vocalization could occur without obvious LFP spikes, however, when phase-phase coupling of alpha oscillations were accentuated between the NAc, ACC, and the primary motor cortex. These findings contrasted with myoclonic motor tics induced by disinhibition of the dorsolateral putamen, where PET activity was confined to the ipsilateral sensorimotor system and LFP spikes always preceded motor tics. We propose that vocal tics emerge as a consequence of dysrhythmic alpha coupling between critical nodes in the limbic and motor networks. |
記述: | トゥレット障害の発症メカニズム解明に新展開 --音声チック症状を呈する霊長類モデルを開発--. 京都大学プレスリリース. 2016-01-21. |
著作権等: | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/218583 |
DOI(出版社版): | 10.1016/j.neuron.2015.12.025 |
PubMed ID: | 26796690 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2016-01-21 |
出現コレクション: | 学術雑誌掲載論文等 |
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