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タイトル: Essential Roles of Natural Products and Gaseous Mediators on Neuronal Cell Death or Survival
著者: Mikami, Yoshinori
Kakizawa, Sho  kyouindb  KAKEN_id
Yamazawa, Toshiko
著者名の別形: 柿澤, 昌
キーワード: chlorogenic acid
glutamate neurotoxicity
hydrogen sulfide
neuroprotection
nitric oxide
発行日: 29-Sep-2016
出版者: MDPI AG
誌名: International Journal of Molecular Sciences
巻: 17
号: 10
論文番号: 1652
抄録: Although precise cellular and molecular mechanisms underlying neurodegeneration still remain enigmatic, key factors associated with degenerative disorders, such as glutamate toxicity and oxidative stress, have been recently identified. Accordingly, there has been growing interest in examining the effects of exogenous and endogenous molecules on neuroprotection and neurodegeneration. In this paper, we review recent studies on neuroprotective and/or neurodegenerative effects of natural products, such as caffeic acid and chlorogenic acid, and gaseous mediators, including hydrogen sulfide and nitric oxide. Furthermore, possible molecular mechanisms of these molecules in relation to glutamate signals are discussed. Insight into the pathophysiological role of these molecules will make progress in our understanding of molecular mechanisms underlying neurodegenerative diseases, and is expected to lead to potential therapeutic approaches.
著作権等: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
URI: http://hdl.handle.net/2433/218628
DOI(出版社版): 10.3390/ijms17101652
出現コレクション:学術雑誌掲載論文等

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