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Title: Essential Roles of Natural Products and Gaseous Mediators on Neuronal Cell Death or Survival
Authors: Mikami, Yoshinori
Kakizawa, Sho  kyouindb  KAKEN_id  orcid (unconfirmed)
Yamazawa, Toshiko
Author's alias: 柿澤, 昌
Keywords: chlorogenic acid
glutamate neurotoxicity
hydrogen sulfide
nitric oxide
Issue Date: 29-Sep-2016
Publisher: MDPI AG
Journal title: International Journal of Molecular Sciences
Volume: 17
Issue: 10
Thesis number: 1652
Abstract: Although precise cellular and molecular mechanisms underlying neurodegeneration still remain enigmatic, key factors associated with degenerative disorders, such as glutamate toxicity and oxidative stress, have been recently identified. Accordingly, there has been growing interest in examining the effects of exogenous and endogenous molecules on neuroprotection and neurodegeneration. In this paper, we review recent studies on neuroprotective and/or neurodegenerative effects of natural products, such as caffeic acid and chlorogenic acid, and gaseous mediators, including hydrogen sulfide and nitric oxide. Furthermore, possible molecular mechanisms of these molecules in relation to glutamate signals are discussed. Insight into the pathophysiological role of these molecules will make progress in our understanding of molecular mechanisms underlying neurodegenerative diseases, and is expected to lead to potential therapeutic approaches.
Rights: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (
DOI(Published Version): 10.3390/ijms17101652
PubMed ID: 27690018
Appears in Collections:Journal Articles

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