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Title: Grading Meningioma : A Comparative Study of Thallium-SPECT and FDG-PET
Authors: Okuchi, Sachi  kyouindb  KAKEN_id  orcid (unconfirmed)
Okada, Tomohisa  kyouindb  KAKEN_id  orcid (unconfirmed)
Yamamoto, Akira  kyouindb  KAKEN_id  orcid (unconfirmed)
Kanagaki, Mitsunori
Fushimi, Yasutaka  kyouindb  KAKEN_id  orcid (unconfirmed)
Okada, Tsutomu  kyouindb  KAKEN_id
Yamauchi, Moritaka
Kataoka, Masako  kyouindb  KAKEN_id  orcid (unconfirmed)
Arakawa, Yoshiki  kyouindb  KAKEN_id  orcid (unconfirmed)
Takahashi, Jun C.
Minamiguchi, Sachiko  kyouindb  KAKEN_id
Miyamoto, Susumu
Togashi, Kaori  kyouindb  KAKEN_id
Keywords: Medicine(all)
Issue Date: Feb-2015
Publisher: Lippincott Williams and Wilkins
Journal title: Medicine (United States)
Volume: 94
Issue: 6
Abstract: The purpose was to compare capability of fluorine-18 fluorodeoxyglucose (FDG)-PET and thallium-201 (Tl)-SPECT for grading meningioma. This retrospective study was conducted as a case-control study under approval by the institutional review board. In the hospital information system, 67 patients (22 men and 45 women) who had both FDG-PET and Tl-SPECT preoperative examinations were found with histopathologic diagnosis of meningioma. The maximum FDG uptake values of the tumors were measured, and they were standardized to the whole body (SUVmax) and normalized as gray matter ratio (SUVRmax). Mean and maximum Tl uptake ratios (TURmean and TURmax, respectively) of the tumors were measured and normalized as ratios to those of the contralateral normal brain. Receiver-operating characteristic curve analyses of the 4 indexes were conducted for differentiation between low- and high-grade meningiomas, and areas under the curves (AUCs) were compared. Correlation coefficients were calculated between these indexes and Ki-67. Fifty-six meningiomas were classified as grade I (low grade), and 11 were grade II or III (high grade). In all 4 indexes, a significant difference was observed between low- and high-grade meningiomas (P<0.05). AUCs were 0.817 (SUVmax), 0.781 (SUVRmax), 0.810 (TURmean), and 0.831 (TURmax), and no significant difference was observed among the indexes. Their sensitivity and specificity were 72.7% to 90.9% and 71.4% to 87.5%, respectively. Correlation of the 4 indexes to Ki-67 was statistically significant, but coefficients were relatively low (0.273-0.355). Tl-SPECT, which can be used at hospitals without a cyclotron or an FDG distribution network, has high diagnostic capability of meningioma grades comparable to FDG-PET.
Rights: © 2015 Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially.
DOI(Published Version): 10.1097/MD.0000000000000549
PubMed ID: 25674763
Appears in Collections:Journal Articles

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