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タイトル: Continuous-Flow Synthesis of N-Succinimidyl 4-[18F]fluorobenzoate Using a Single Microfluidic Chip
著者: Kimura, Hiroyuki
Tomatsu, Kenji
Saiki, Hidekazu
Arimitsu, Kenji
Ono, Masahiro  kyouindb  KAKEN_id
Kawashima, Hidekazu
Iwata, Ren
Nakanishi, Hiroaki
Ozeki, Eiichi
Kuge, Yuji
Saji, Hideo
著者名の別形: 佐治, 英郎
発行日: 13-Jul-2016
出版者: Public Library of Science
誌名: PLOS ONE
巻: 11
号: 7
論文番号: e0159303
抄録: In the field of positron emission tomography (PET) radiochemistry, compact microreactors provide reliable and reproducible synthesis methods that reduce the use of expensive precursors for radiolabeling and make effective use of the limited space in a hot cell. To develop more compact microreactors for radiosynthesis of 18F-labeled compounds required for the multistep procedure, we attempted radiosynthesis of N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) via a three-step procedure using a microreactor. We examined individual steps for [18F]SFB using a batch reactor and microreactor and developed a new continuous-flow synthetic method with a single microfluidic chip to achieve rapid and efficient radiosynthesis of [18F]SFB. In the synthesis of [18F]SFB using this continuous-flow method, the three-step reaction was successfully completed within 6.5 min and the radiochemical yield was 64 ± 2% (n = 5). In addition, it was shown that the quality of [18F]SFB synthesized on this method was equal to that synthesized by conventional methods using a batch reactor in the radiolabeling of bovine serum albumin with [18F]SFB.
著作権等: © 2016 Kimura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: http://hdl.handle.net/2433/218702
DOI(出版社版): 10.1371/journal.pone.0159303
PubMed ID: 27410684
出現コレクション:学術雑誌掲載論文等

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