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タイトル: | Continuous-Flow Synthesis of N-Succinimidyl 4-[18F]fluorobenzoate Using a Single Microfluidic Chip |
著者: | Kimura, Hiroyuki Tomatsu, Kenji Saiki, Hidekazu Arimitsu, Kenji Ono, Masahiro https://orcid.org/0000-0002-2497-039X (unconfirmed) Kawashima, Hidekazu Iwata, Ren Nakanishi, Hiroaki Ozeki, Eiichi Kuge, Yuji Saji, Hideo |
著者名の別形: | 佐治, 英郎 |
発行日: | 13-Jul-2016 |
出版者: | Public Library of Science |
誌名: | PLOS ONE |
巻: | 11 |
号: | 7 |
論文番号: | e0159303 |
抄録: | In the field of positron emission tomography (PET) radiochemistry, compact microreactors provide reliable and reproducible synthesis methods that reduce the use of expensive precursors for radiolabeling and make effective use of the limited space in a hot cell. To develop more compact microreactors for radiosynthesis of 18F-labeled compounds required for the multistep procedure, we attempted radiosynthesis of N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) via a three-step procedure using a microreactor. We examined individual steps for [18F]SFB using a batch reactor and microreactor and developed a new continuous-flow synthetic method with a single microfluidic chip to achieve rapid and efficient radiosynthesis of [18F]SFB. In the synthesis of [18F]SFB using this continuous-flow method, the three-step reaction was successfully completed within 6.5 min and the radiochemical yield was 64 ± 2% (n = 5). In addition, it was shown that the quality of [18F]SFB synthesized on this method was equal to that synthesized by conventional methods using a batch reactor in the radiolabeling of bovine serum albumin with [18F]SFB. |
著作権等: | © 2016 Kimura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | http://hdl.handle.net/2433/218702 |
DOI(出版社版): | 10.1371/journal.pone.0159303 |
PubMed ID: | 27410684 |
出現コレクション: | 学術雑誌掲載論文等 |
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