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タイトル: | Light responsive metal-organic frameworks as controllable CO-releasing cell culture substrates |
著者: | Diring, Stéphane Carné-Sánchez, Arnau Zhang, Ji Cheng Ikemura, Shuya Kim, Chiwon Inaba, Hiroshi Kitagawa, Susumu https://orcid.org/0000-0001-6956-9543 (unconfirmed) Furukawa, Shuhei https://orcid.org/0000-0003-3849-8038 (unconfirmed) |
著者名の別形: | 北川, 進 古川, 修平 |
発行日: | 2017 |
出版者: | Royal Society of Chemistry (RSC) |
誌名: | Chemical Science |
巻: | 8 |
開始ページ: | 2381 |
終了ページ: | 2386 |
抄録: | A new carbon monoxide (CO)-releasing material has been developed by embedding a manganese carbonyl complex, MnBr(bpydc)(CO)3 (bpydc = 5, 5′-dicarboxylate-2, 2′-bipyridine) into a highly robust Zr(iv)-based metal-organic framework (MOF). Efficient and controllable CO-release was achieved under exposure to low intensity visible light. Size-controllable nanocrystals of the photoactive MOF were obtained and their CO-releasing properties were correlated with their crystal sizes. The photoactive crystals were processed into cellular substrates with a biocompatible polymer matrix, and the light-induced delivery of CO and its subsequent cellular uptake were monitored using a fluorescent CO-probe. The results discussed here demonstrate a new opportunity to use MOFs as macromolecular scaffolds towards CO-releasing materials and the advantage of MOFs for high CO payloads, which is essential in future therapeutic applications. |
著作権等: | © The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
URI: | http://hdl.handle.net/2433/218793 |
DOI(出版社版): | 10.1039/c6sc04824b |
PubMed ID: | 28451343 |
出現コレクション: | 学術雑誌掲載論文等 |
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