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Title: <i>In vitro</i> host range of feline morbillivirus
Authors: SAKAGUCHI, Shoichi
KOIDE, Rie
MIYAZAWA, Takayuki  kyouindb  KAKEN_id
Author's alias: 坂口, 翔一
小出, りえ
宮沢, 孝幸
Keywords: cat
cell tropism
cross-species transmission
feline morbillivirus
host range
Issue Date: 2015
Publisher: Japanese Society of Veterinary Science
Journal title: The Journal of veterinary medical science
Volume: 77
Issue: 11
Start page: 1485
End page: 1487
Abstract: Feline morbillivirus (FmoPV) is an emerging virus in cats, which is associated with tubulointerstitial nephritis. To study the in vitro host range of FmoPV, we inoculated FmoPV strain SS1 to 32 cell lines originated from 13 species and cultured for 2 weeks, followed by RNA extraction and reverse-transcription-polymerase chain reaction for FmoPV detection. As a result, only cell lines derived from cats and African green monkeys were susceptible to FmoPV. FmoPV infects diverse feline cell lines: epithelial, fibroblastic, lymphoid and glial cells. These results indicate that the receptor (s) for FmoPV are ubiquitously expressed in cats. No infectivity of FmoPV was observed in human cell lines, which suggests least threatening of cross-species transmission of FmoPV from cats to humans.
Rights: ©2015 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License <http://creativecommons.org/licenses/by-nc-nd/3.0/>.
URI: http://hdl.handle.net/2433/219558
DOI(Published Version): 10.1292/jvms.15-0213
PubMed ID: 26027844
Appears in Collections:Journal Articles

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