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タイトル: | Optical Coherence Tomography Angiography to Estimate Retinal Blood Flow in Eyes with Retinitis Pigmentosa |
著者: | Sugahara, Masako Miyata, Manabu https://orcid.org/0000-0002-7574-1749 (unconfirmed) Ishihara, Kenji Gotoh, Norimoto Morooka, Satoshi Ogino, Ken Hasegawa, Tomoko Hirashima, Takako Yoshikawa, Munemitsu Hata, Masayuki Muraoka, Yuki Ooto, Sotaro Yamashiro, Kenji Yoshimura, Nagahisa |
著者名の別形: | 宮田, 学 |
キーワード: | Eye diseases Medical research |
発行日: | 13-Apr-2017 |
出版者: | Springer Nature |
誌名: | Scientific Reports |
巻: | 7 |
論文番号: | 46396 |
抄録: | Ophthalmologists sometimes face difficulties in identifying the origin of visual acuity (VA) loss in a retinitis pigmentosa (RP) patient, particularly before cataract surgery: cataract or the retinal disease state. Therefore, it is important to identify the significant factors correlating with VA. Nowadays, retinal blood flow in superficial and deep layers can be estimated non-invasively using optical coherence tomography angiography (OCTA). We estimated blood flow per retinal layer by using OCTA; investigated the correlation between VA and other parameters including blood flow and retinal thickness; and identified the most associated factor with VA in patients with RP. OCTA images in 68 of consecutive 110 Japanese RP patients were analysable (analysable RP group). Thirty-two age- and axial length-matched healthy eyes (control group) were studied. In the analysable RP group, the parafoveal flow density in superficial and deep layers was 47.0 ± 4.9% and 52.4 ± 5.5%, respectively, which was significantly lower than that in controls. Using multivariate analysis, we found that the parafoveal flow density in the deep layer and superficial foveal avascular area were the factors associated with VA. Non-invasive estimation of retinal blood flow per retinal layer using OCTA is useful for predicting VA in RP patients. |
著作権等: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
URI: | http://hdl.handle.net/2433/224810 |
DOI(出版社版): | 10.1038/srep46396 |
PubMed ID: | 28406171 |
出現コレクション: | 学術雑誌掲載論文等 |
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