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Title: Quantitative assessment of gadolinium deposition in dentate nucleus using quantitative susceptibility mapping
Authors: Hinoda, Takuya  kyouindb  KAKEN_id  orcid (unconfirmed)
Fushimi, Yasutaka  kyouindb  KAKEN_id  orcid (unconfirmed)
Okada, Tomohisa  kyouindb  KAKEN_id  orcid (unconfirmed)
Arakawa, Yoshiki  kyouindb  KAKEN_id  orcid (unconfirmed)
Liu, Chunlei
Yamamoto, Akira  kyouindb  KAKEN_id  orcid (unconfirmed)
Okada, Tsutomu
Yoshida, Kazumichi  kyouindb  KAKEN_id  orcid (unconfirmed)
Miyamoto, Susumu
Togashi, Kaori
Author's alias: 日野田, 卓也
伏見, 育崇
山本, 憲
宮本, 享
富樫, かおり
Keywords: magnetic resonance imaging
quantitative susceptibility mapping
gadolinium-based contrast agents
dentate nucleus
Issue Date: May-2017
Publisher: John Wiley and Sons Inc.
Journal title: Journal of Magnetic Resonance Imaging
Volume: 45
Issue: 5
Start page: 1352
End page: 1358
Abstract: Purpose: Gadolinium deposition in dentate nucleus (DN) has been reported after serial administration of gadolinium-based contrast agents (GBCAs). Gadolinium complexes have paramagnetic properties; therefore, we evaluated susceptibility changes of gadolinium deposition in DN using quantitative susceptibility mapping (QSM) for patients after serial administration of GBCAs. Materials and Methods: In all, 48 patients with brain tumors, who had had serial GBCA administrations (GBCA group), and 48 healthy volunteers without any history of GBCA administrations (non-GBCA group) were enrolled in this study. Susceptibility values in DN on QSM and DN-to-cerebellum signal intensity ratios on unenhanced T1-weighted images (T1 ratios) on 3T were analyzed. The relationship between the number of times of GBCA administrations and susceptibility values or T1 ratios were evaluated in the GBCA group. Results: Susceptibility values at DN in the GBCA group were 0.107±0.029ppm, and significantly higher than those of the non-GBCA group (0.079±0.025ppm) (P < 0.0001). T1 ratios in DN of the GBCA group were 1.059±0.070, and also significantly higher than that of the non-GBCA group (0.993±0.016) (P < 0.0001). Spearman rank correlation coefficients between susceptibility values and the number of times of linear GBCA administration showed a modest significant correlation (ρ=0.45, P=0.0015). There was good correlation between T1 ratios and the number of times of linear GBCA administration, as reported previously (ρ=0.76, P < 0.0001). Conclusion: Susceptibility values on QSM in DN of the GBCA group, after serial administration of GBCAs, were significantly higher than those of the non-GBCA group.
Rights: This is the accepted version of the following article: [Hinoda, T., Fushimi, Y., Okada, T., Arakawa, Y., Liu, C., Yamamoto, A., Okada, T., Yoshida, K., Miyamoto, S. and Togashi, K. (2017), Quantitative assessment of gadolinium deposition in dentate nucleus using quantitative susceptibility mapping. J. Magn. Reson. Imaging, 45: 1352–1358], which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
The full-text file will be made open to the public on 18 APR 2018 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1002/jmri.25490
PubMed ID: 27664936
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