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Title: Visuomotor signals for reaching movements in the rostro-dorsal sector of the monkey thalamic reticular nucleus
Authors: Saga, Yosuke
Nakayama, Yoshihisa
Inoue, Ken-ichi
Yamagata, Tomoko
Hashimoto, Masashi
Tremblay, Léon
Takada, Masahiko  kyouindb  KAKEN_id
Hoshi, Eiji
Author's alias: 高田, 昌彦
Keywords: action
nonhuman primates
premotor cortex
reaching movement
visuomotor control
Issue Date: May-2017
Publisher: Wiley-Blackwell
Journal title: European Journal of Neuroscience
Volume: 45
Issue: 9
Start page: 1186
End page: 1199
Abstract: The thalamic reticular nucleus (TRN) collects inputs from the cerebral cortex and thalamus and, in turn, sends inhibitory outputs to the thalamic relay nuclei. This unique connectivity suggests that the TRN plays a pivotal role in regulating information flow through the thalamus. Here, we analyzed the roles of TRN neurons in visually guided reaching movements. We first used retrograde transneuronal labeling with rabies virus, and showed that the rostro-dorsal sector of the TRN (TRNrd) projected disynaptically to the ventral premotor cortex (PMv). In other experiments, we recorded neurons from the TRNrd or PMv while monkeys performed a visuomotor task. We found that neurons in the TRNrd and PMv showed visual-, set-, and movement-related activity modulation. These results indicate that the TRNrd, as well as the PMv, is involved in the reception of visual signals and in the preparation and execution of reaching movements. The fraction of neurons that were non-selective for the location of visual signals or the direction of reaching movements was greater in the TRNrd than in the PMv. Furthermore, the fraction of neurons whose activity increased from the baseline was greater in the TRNrd than in the PMv. The timing of activity modulation of visual-related and movement-related neurons was similar in TRNrd and PMv neurons. Overall, our data suggest that TRNrd neurons provide motor thalamic nuclei with inhibitory inputs that are predominantly devoid of spatial selectivity, and that these signals modulate how these nuclei engage in both sensory processing and motor output during visually guided reaching behavior.
Rights: This is the peer reviewed version of the following article: [Saga, Y., Nakayama, Y., Inoue, K.-i., Yamagata, T., Hashimoto, M., Tremblay, L., Takada, M., Hoshi, E. (2017), Visuomotor signals for reaching movements in the rostro-dorsal sector of the monkey thalamic reticular nucleus. European Journal of Neuroscience, 45: 1186–1199], which has been published in final form at https://doi.org/10.1111/ejn.13421. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
The full-text file will be made open to the public on 26 APR 2018 in accordance with publisher's 'Terms and Conditions for Self-Archiving'.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/224995
DOI(Published Version): 10.1111/ejn.13421
Appears in Collections:Journal Articles

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