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タイトル: | Visuomotor signals for reaching movements in the rostro-dorsal sector of the monkey thalamic reticular nucleus |
著者: | Saga, Yosuke Nakayama, Yoshihisa Inoue, Ken-ichi Yamagata, Tomoko Hashimoto, Masashi Tremblay, Léon Takada, Masahiko https://orcid.org/0000-0003-0774-2333 (unconfirmed) Hoshi, Eiji |
著者名の別形: | 高田, 昌彦 |
キーワード: | action nonhuman primates premotor cortex reaching movement visuomotor control |
発行日: | May-2017 |
出版者: | Wiley-Blackwell |
誌名: | European Journal of Neuroscience |
巻: | 45 |
号: | 9 |
開始ページ: | 1186 |
終了ページ: | 1199 |
抄録: | The thalamic reticular nucleus (TRN) collects inputs from the cerebral cortex and thalamus and, in turn, sends inhibitory outputs to the thalamic relay nuclei. This unique connectivity suggests that the TRN plays a pivotal role in regulating information flow through the thalamus. Here, we analyzed the roles of TRN neurons in visually guided reaching movements. We first used retrograde transneuronal labeling with rabies virus, and showed that the rostro-dorsal sector of the TRN (TRNrd) projected disynaptically to the ventral premotor cortex (PMv). In other experiments, we recorded neurons from the TRNrd or PMv while monkeys performed a visuomotor task. We found that neurons in the TRNrd and PMv showed visual-, set-, and movement-related activity modulation. These results indicate that the TRNrd, as well as the PMv, is involved in the reception of visual signals and in the preparation and execution of reaching movements. The fraction of neurons that were non-selective for the location of visual signals or the direction of reaching movements was greater in the TRNrd than in the PMv. Furthermore, the fraction of neurons whose activity increased from the baseline was greater in the TRNrd than in the PMv. The timing of activity modulation of visual-related and movement-related neurons was similar in TRNrd and PMv neurons. Overall, our data suggest that TRNrd neurons provide motor thalamic nuclei with inhibitory inputs that are predominantly devoid of spatial selectivity, and that these signals modulate how these nuclei engage in both sensory processing and motor output during visually guided reaching behavior. |
著作権等: | This is the peer reviewed version of the following article: [Saga, Y., Nakayama, Y., Inoue, K.-i., Yamagata, T., Hashimoto, M., Tremblay, L., Takada, M., Hoshi, E. (2017), Visuomotor signals for reaching movements in the rostro-dorsal sector of the monkey thalamic reticular nucleus. European Journal of Neuroscience, 45: 1186–1199], which has been published in final form at https://doi.org/10.1111/ejn.13421. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. The full-text file will be made open to the public on 26 APR 2018 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/224995 |
DOI(出版社版): | 10.1111/ejn.13421 |
PubMed ID: | 27706860 |
出現コレクション: | 学術雑誌掲載論文等 |
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