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タイトル: | Potential involvement of dietary advanced glycation end products in impairment of skeletal muscle growth and muscle contractile function in mice |
著者: | Egawa, Tatsuro https://orcid.org/0000-0001-9363-1589 (unconfirmed) Tsuda, Satoshi Goto, Ayumi Ohno, Yoshitaka Yokoyama, Shingo Goto, Katsumasa Hayashi, Tatsuya https://orcid.org/0000-0001-7600-4735 (unconfirmed) |
著者名の別形: | 江川, 達郎 |
キーワード: | Muscle strength Muscle fatigue resistance Muscle force production Myogenesis Protein synthesis |
発行日: | Jan-2017 |
出版者: | Cambridge University Press (CUP) |
誌名: | British Journal of Nutrition |
巻: | 117 |
開始ページ: | 21 |
終了ページ: | 29 |
抄録: | Diets enriched with advanced glycation end products (AGE) have recently been related to muscle dysfunction processes. However, it remains unclear whether long-term exposure to an AGE-enriched diet impacts physiological characteristics of skeletal muscles. Therefore, we explored the differences in skeletal muscle mass, contractile function and molecular responses between mice receiving a diet high in AGE (H-AGE) and low in AGE (L-AGE) for 16 weeks. There were no significant differences between L-AGE and H-AGE mice with regard to body weight, food intake or epididymal fat pad weight. However, extensor digitorum longus (EDL) and plantaris (PLA) muscle weights in H-AGE mice were lower compared with L-AGE mice. Higher levels of N[ε] -(carboxymethyl)-l-lysine, a marker for AGE, in EDL muscles of H-AGE mice were observed compared with L-AGE mice. H-AGE mice showed lower muscle strength and endurance in vivo and lower muscle force production of PLA muscle in vitro. mRNA expression levels of myogenic factors including myogenic factor 5 and myogenic differentiation in EDL muscle were lower in H-AGE mice compared with L-AGE mice. The phosphorylation status of 70-kDa ribosomal protein S6 kinase Thr[389], an indicator of protein synthesis signalling, was lower in EDL muscle of H-AGE mice than that of L-AGE mice. These findings suggest that long-term exposure to an AGE-enriched diet impairs skeletal muscle growth and muscle contractile function, and that these muscle dysfunctions may be attributed to the inhibition of myogenic potential and protein synthesis. |
著作権等: | © The Authors 2017 The full-text file will be made open to the public on 1 January 2018 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. |
URI: | http://hdl.handle.net/2433/225061 |
DOI(出版社版): | 10.1017/S0007114516004591 |
PubMed ID: | 28093090 |
出現コレクション: | 学術雑誌掲載論文等 |
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