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Title: Increased dystrophin mRNA and protein levels in atrophic skeletal muscles in streptozotocin-induced diabetic rats
Authors: Egawa, Tatsuro
Masuda, Shinya
Goto, Katsumasa
Hayashi, Tatsuya
Author's alias: 江川, 達郎
林, 達也
Keywords: dystrophin
atrophic muscle
hyperglycemia
insulin
streptozotocin
Issue Date: 2012
Publisher: Japanese Society of Physical Fitness and Sports Medicine
Journal title: The Journal of Physical Fitness and Sports Medicine
Volume: 1
Issue: 4
Start page: 709
End page: 713
Abstract: Severe diabetes frequently induces skeletal muscle atrophy, and dystrophin disruption has been implicated in the pathogenesis of skeletal muscle atrophy. We hypothesized that the downregulation of dystrophin expression causes diabetic-induced muscle atrophy, and investigated whether dystrophin mRNA and protein levels are altered in the atrophic muscles of diabetic rats. Rats received a single intravenous injection of streptozotocin (STZ) (45 mg/kg body weight). Slow-twitch soleus and fast-twitch extensor digitorum longus muscles were dissected from each rat 4 or 12 weeks after the STZ injection. The STZ group had significantly higher blood glucose levels and lower body weights than the control group. The relative muscle weight per body weight was also lower in the STZ group than in the control group, and these changes accompanied a reduction in glucose transporter 4. The phosphorylation of Akt Ser[473] and p70 S6 kinase Thr[389] was lower in the soleus and extensor digitorum longus muscles of the diabetic rats than in those of the control rats. In contrast, dystrophin mRNA and protein expression were higher in the muscles of the diabetic rats than in those of the control rats. A histochemical study showed that the localization of dystrophin did not differ between the muscles of the control and diabetic rats. Our data suggest that the downregulation of dystrophin is not a general characteristic associated with skeletal muscle in diabetes.
Rights: This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/225064
DOI(Published Version): 10.7600/jpfsm.1.709
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