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Title: A Comparison of Conventional Collagen Sponge and Collagen-Gelatin Sponge in Wound Healing
Authors: Jinno, Chizuru
Morimoto, Naoki  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-0712-3172 (unconfirmed)
Ito, Ran
Sakamoto, Michiharu  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-0024-6807 (unconfirmed)
Ogino, Shuichi
Taira, Tsuguyoshi
Suzuki, Shigehiko
Author's alias: 神野, 千鶴
伊藤, 蘭
坂本, 道治
鈴木, 茂彦
Issue Date: 2016
Publisher: Hindawi Publishing Corporation
Journal title: BioMed Research International
Volume: 2016
Thesis number: 4567146
Abstract: The objective of this study was to compare the effectiveness of the collagen-gelatin sponge (CGS) with that of the collagen sponge (CS) in dermis-like tissue regeneration. CGS, which achieves the sustained release of basic fibroblast growth factor (bFGF), is a promising material in wound healing. In the present study, we evaluated and compared CGSs and conventional CSs. We prepared 8 mm full-thickness skin defects on the backs of rats. Either CGSs or CSs were impregnated with normal saline solution (NSS) or 7 μg/cm2 of bFGF solution and implanted into the defects. At 1 and 2 weeks after implantation, tissue specimens were obtained from the rats of each group (n=3, total n=24 ). The wound area, neoepithelial length, dermis-like tissue area, and the number and area of capillaries were evaluated at 1 and 2 weeks after implantation. There were no significant differences in the CGS without bFGF and CS groups. Significant improvements were observed in the neoepithelial length, the dermis-like tissue area, and the number of newly formed capillaries in the group of rats that received CGSs impregnated with bFGF. The effects on epithelialization, granulation, and vascularization of wound healing demonstrated that, as a scaffold, CGSs are equal or superior to conventional CSs.
Rights: © 2016 Chizuru Jinno et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2433/225080
DOI(Published Version): 10.1155/2016/4567146
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