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DCフィールド | 値 | 言語 |
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dc.contributor.author | Morimoto, Daichi | en |
dc.contributor.author | Walinda, Erik | en |
dc.contributor.author | Sugase, Kenji | en |
dc.contributor.author | Shirakawa, Masahiro | en |
dc.contributor.alternative | 森本, 大智 | ja |
dc.contributor.alternative | 菅瀬, 謙治 | ja |
dc.date.accessioned | 2017-07-04T02:59:18Z | - |
dc.date.available | 2017-07-04T02:59:18Z | - |
dc.date.issued | 2017-05-27 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/2433/226315 | - |
dc.description.abstract | Most intracellular proteins are subjected to post-translational modification by ubiquitin. Accordingly, it is of fundamental importance to investigate the biological and physicochemical effects of ubiquitylation on substrate proteins. However, preparation of ubiquitylated proteins by an enzymatic synthesis bears limitations in terms of yield and site-specificity. Recently established chemical ubiquitylation methodologies can overcome these problems and provide a new understanding of ubiquitylation. Herein we describe the recent chemical ubiquitylation procedures with a focus on the effects of ubiquitylation on target proteins revealed by the synthetic approach. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | en |
dc.rights | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. | en |
dc.rights | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0). | en |
dc.subject | ubiquitin | en |
dc.subject | post-translational modification | en |
dc.subject | chemical ubiquitylation | en |
dc.subject | site-directed conjugation | en |
dc.title | Biological and physicochemical functions of ubiquitylation revealed by synthetic chemistry approaches | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | International Journal of Molecular Sciences | en |
dc.identifier.volume | 18 | - |
dc.identifier.issue | 6 | - |
dc.relation.doi | 10.3390/ijms18061145 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 1145 | - |
dc.identifier.pmid | 28555012 | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 1661-7827 | - |
dc.identifier.eissn | 1660-4601 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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