ダウンロード数: 168
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
srep29920.pdf | 1.08 MB | Adobe PDF | 見る/開く |
タイトル: | Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1 |
著者: | Murakami, Yuki Ishibashi, Takaaki Tomita, Eiichi Imamura, Yukio Tashiro, Tomoyuki Watcharanurak, Kanitta Nishikawa, Makiya Takahashi, Yuki https://orcid.org/0000-0002-8772-2772 (unconfirmed) Takakura, Yoshinobu https://orcid.org/0000-0002-7359-2647 (unconfirmed) Mitani, Satoko Fujigaki, Hidetsugu Ohta, Yoshiji Kubo, Hisako Mamiya, Takayoshi Nabeshima, Toshitaka Kim, Hyoung-Chun Yamamoto, Yasuko Saito, Kuniaki |
著者名の別形: | 村上, 由希 田代, 智之 西川, 元也 高橋, 有己 髙倉, 喜信 山本, 康子 斉藤, 邦明 |
キーワード: | Depression Experimental models of disease |
発行日: | 20-Jul-2016 |
出版者: | Springer Nature |
誌名: | Scientific Reports |
巻: | 6 |
論文番号: | 29920 |
抄録: | Depression is known to occur frequently in chronic hepatitis C viral (HCV) patients receiving interferon (IFN)-α therapy. In this study, we investigated whether indoleamine 2, 3-dioxygenase1 (IDO1)-mediated tryptophan (TRP) metabolism plays a critical role in depression occurring as a side effect of IFN-α therapy. Increases in serum kynurenine (KYN) and 3-hydroxykynurenine (3-HK) concentrations and in the ratios of KYN/TRP and 3-HK/kynurenic acid (KA) were much larger in depressive HCV patients than in non-depressed patients following therapy. Furthermore, transfection of a plasmid continuously expressing murine IFN-γ into normal mice significantly increased depression-like behavior. IFN-γ gene transfer also resulted in a decrease in serum TRP levels in the mice while KYN and 3-HK levels were significantly increased in both serum and frontal cortex. Genetic deletion of IDO1 in mice abrogated both the increase in depression-like behavior and the elevation in TRP metabolites’ levels, and the turnover of serotonin in the frontal cortex after IFN-γ gene transfer. These results indicate that the KYN pathway of IDO1-mediated TRP metabolism plays a critical role in depressive symptoms associated with IFN-α therapy. |
著作権等: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. |
URI: | http://hdl.handle.net/2433/226364 |
DOI(出版社版): | 10.1038/srep29920 |
PubMed ID: | 27436416 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。