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j.stemcr.2016.09.002.pdf4.49 MBAdobe PDF見る/開く
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dc.contributor.authorMao, Binen
dc.contributor.authorHuang, Shuen
dc.contributor.authorLu, Xulinen
dc.contributor.authorSun, Wencuien
dc.contributor.authorZhou, Yaen
dc.contributor.authorPan, Xuen
dc.contributor.authorYu, Jinfengen
dc.contributor.authorLai, Mowenen
dc.contributor.authorChen, Boen
dc.contributor.authorZhou, Qiongxiuen
dc.contributor.authorMao, Songen
dc.contributor.authorBian, Guohuien
dc.contributor.authorZhou, Jiaxien
dc.contributor.authorNakahata, Tatsutoshien
dc.contributor.authorMa, Fengen
dc.contributor.alternative中畑, 龍俊ja
dc.date.accessioned2017-07-14T06:50:27Z-
dc.date.available2017-07-14T06:50:27Z-
dc.date.issued2016-11-08-
dc.identifier.issn2213-6711-
dc.identifier.urihttp://hdl.handle.net/2433/226436-
dc.description.abstractThe development of human erythroid cells has been mostly examined in models of adult hematopoiesis, while their early derivation during embryonic and fetal stages is largely unknown. We observed the development and maturation of erythroblasts derived from human pluripotent stem cells (hPSCs) by an efficient co-culture system. These hPSC-derived early erythroblasts initially showed definitive characteristics with a glycophorin A+ (GPA+) CD34lowCD36− phenotype and were distinct from adult CD34+ cell-derived ones. After losing CD34 expression, early GPA+CD36− erythroblasts matured into GPA+CD36low/+ stage as the latter expressed higher levels of β-globin along with a gradual loss of mesodermal and endothelial properties, and terminally suppressed CD36. We establish a unique in vitro model to trace the early development of hPSC-derived erythroblasts by serial expression of CD34, GPA, and CD36. Our findings may provide insight into the understanding of human early erythropoiesis and, ultimately, therapeutic potential.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherElsevier BVen
dc.rights© 2016 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en
dc.subjecthESCen
dc.subjecthiPSCen
dc.subjecthematopoiesisen
dc.subjectdevelopmenten
dc.subjecterythroblastsen
dc.subjecterythropoiesisen
dc.subjectendothelial cellsen
dc.subjectGPAen
dc.subjectCD36en
dc.subjectCD34en
dc.titleEarly Development of Definitive Erythroblasts from Human Pluripotent Stem Cells Defined by Expression of Glycophorin A/CD235a, CD34, and CD36en
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleStem Cell Reportsen
dc.identifier.volume7-
dc.identifier.issue5-
dc.identifier.spage869-
dc.identifier.epage883-
dc.relation.doi10.1016/j.stemcr.2016.09.002-
dc.textversionpublisher-
dc.identifier.pmid27720903-
dcterms.accessRightsopen access-
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