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Title: Boron Neutron Capture Therapy for Malignant Brain Tumors
Authors: MIYATAKE, Shin-Ichi
KUROIWA, Toshihiko
SUZUKI, Minoru  kyouindb  KAKEN_id  orcid (unconfirmed)
KONDO, Natsuko  kyouindb  KAKEN_id
ONO, Koji
Author's alias: 鈴木, 実
近藤, 夏子
小野, 公二
Keywords: boron neutron capture therapy
malignant glioma
high-grade meningioma
positron emission tomography
Issue Date: Jul-2016
Publisher: Japan Neurosurgical Society
Journal title: Neurologia medico-chirurgica
Volume: 56
Issue: 7
Start page: 361
End page: 371
Abstract: Boron neutron capture therapy (BNCT) is a biochemically targeted radiotherapy based on the nuclear capture and fission reactions that occur when non-radioactive boron-10, which is a constituent of natural elemental boron, is irradiated with low energy thermal neutrons to yield high linear energy transfer alpha particles and recoiling lithium-7 nuclei. Therefore, BNCT enables the application of a high dose of particle radiation selectively to tumor cells in which boron-10 compound has been accumulated. We applied BNCT using nuclear reactors for 167 cases of malignant brain tumors, including recurrent malignant gliomas, newly diagnosed malignant gliomas, and recurrent high-grade meningiomas from January 2002 to May 2014. Here, we review the principle and history of BNCT. In addition, we introduce fluoride-18-labeled boronophenylalanine positron emission tomography and the clinical results of BNCT for the above-mentioned malignant brain tumors. Finally, we discuss the recent development of accelerators producing epithermal neutron beams. This development could provide an alternative to the current use of specially modified nuclear reactors as a neutron source, and could allow BNCT to be performed in a hospital setting.
Rights: This article is applied Creative Commons Attribution Non-Commercial-NoDerivs License (CC BY-NC-ND) by the publisher.
DOI(Published Version): 10.2176/nmc.ra.2015-0297
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