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Title: Histopathological features of brain arteriovenous malformations in Japanese patients
Authors: HERMANTO, Yulius
TAKAGI, Yasushi
YOSHIDA, Kazumichi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8898-079X (unconfirmed)
ISHII, Akira  kyouindb  KAKEN_id
KIKUCHI, Takayuki  kyouindb  KAKEN_id
FUNAKI, Takeshi  kyouindb  KAKEN_id
MINEHARU, Yohei  kyouindb  KAKEN_id
MIYAMOTO, Susumu
Author's alias: 髙木, 康志
吉田, 和道
石井, 暁
菊池, 隆幸
舟木, 健史
峰晴, 陽平
宮本, 享
Keywords: arteriovenous malformations
histopathological study
clinical features
nidus
Issue Date: Jun-2016
Publisher: Japan Neurosurgical Society
Journal title: Neurologia Medico-Chirurgica
Volume: 56
Issue: 6
Start page: 340
End page: 344
Abstract: Clinical features of high risk brain arteriovenous malformations (BAVMs) are well characterized. However, pathological evidences about the differences that are possessed by high risk patients are still lacking. We reviewed archived routine hematoxylin-eosin specimens from a total of 54 surgical treated BAVMs. The histopathological features in nidus were semi-quantitatively analyzed. We obtained the pathological differences of BAVMs nidus between several clinical features. Among the analyzed pathological features, the significant differences were observed in degree of venous enlargement and intimal hyperplasia. Juvenile, female, diffuse nidus, high Spetzler-Martin grade, and low flow patients had a lesser degree of those parameters compared to adult, male, compact nidus, low Spetzler-Martin grade and high flow patients. High risk profiles of BAVMs patients were well-reflected in the nidus pathology. Therefore, juvenile, female, diffuse nidus, and low flow in Japanese BAVMs patients might have different vascular remodeling process that predispose to higher tendency of hemorrhage.
Rights: This article is applied Creative Commons Attribution Non-Commercial-NoDerivs License (CC BY-NC-ND) by the publisher.
URI: http://hdl.handle.net/2433/226827
DOI(Published Version): 10.2176/nmc.oa.2016-0032
PubMed ID: 27053330
Appears in Collections:Journal Articles

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