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Title: Histopathological Characteristics of Distal Middle Cerebral Artery in Adult and Pediatric Patients with Moyamoya Disease
Authors: TAKAGI, Yasushi
FUNAKI, Takeshi  kyouindb  KAKEN_id
KIKUCHI, Takayuki  kyouindb  KAKEN_id
MINEHARU, Yohei  kyouindb  KAKEN_id
YOSHIDA, Kazumichi  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 髙木, 康志
舟木, 健史
菊池, 隆幸
峰晴, 陽平
吉田, 和道
宮本, 享
Keywords: moyamoya disease
histopathological study
middle cerebral artery
Issue Date: Jun-2016
Publisher: Japan Neurosurgical Society
Journal title: Neurologia Medico-Chirurgica
Volume: 56
Issue: 6
Start page: 345
End page: 349
Abstract: Moyamoya disease (MMD) is a unique progressive steno-occlusive disease of the distal ends of bilateral internal arteries and their proximal branches. The difference in clinical symptoms between adult and children MMD patients has been well recognized. In this study, we sought to investigate the phenomenon through histopathological study. Fifty-one patients underwent surgical procedures for treatment of standard indications of MMD at Kyoto University Hospital. Fifty-nine specimens of MCA were obtained from MMD patients during the surgical procedures. Five MCA samples were also obtained in the same way from control patients. The samples were analyzed by histopathological methods. In this study, MCA specimens from MMD patients had significantly thinner media and thicker intima than control specimens. In subsequent analysis, adult (≥ 20 years) patients had thicker intima of MCA compared to pediatric (< 20 years) patients. There is no difference in internal elastic lamina pathology between adult and pediatric patients. Our results indicated that the pathological feature of MMD in tunica media occurs in both adult and pediatric patients. However, the MMD feature in tunica intima of MCA is more prominent in adult patients. Further analysis from MCA specimens and other researches are necessary to elucidate the pathophysiology of MMD.
Rights: This article is applied Creative Commons Attribution Non-Commercial-NoDerivs License (CC BY-NC-ND) by the publisher.
DOI(Published Version): 10.2176/nmc.oa.2016-0031
PubMed ID: 27087193
Appears in Collections:Journal Articles

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