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タイトル: | Histopathological Characteristics of Distal Middle Cerebral Artery in Adult and Pediatric Patients with Moyamoya Disease |
著者: | TAKAGI, Yasushi HERMANTO, Yulius TAKAHASHI, Jun C FUNAKI, Takeshi https://orcid.org/0000-0001-9489-7469 (unconfirmed) KIKUCHI, Takayuki MINEHARU, Yohei https://orcid.org/0000-0002-6346-3999 (unconfirmed) YOSHIDA, Kazumichi https://orcid.org/0000-0002-8898-079X (unconfirmed) MIYAMOTO, Susumu |
著者名の別形: | 髙木, 康志 舟木, 健史 菊池, 隆幸 峰晴, 陽平 吉田, 和道 宮本, 享 |
キーワード: | moyamoya disease histopathological study adult pediatric middle cerebral artery |
発行日: | Jun-2016 |
出版者: | Japan Neurosurgical Society |
誌名: | Neurologia Medico-Chirurgica |
巻: | 56 |
号: | 6 |
開始ページ: | 345 |
終了ページ: | 349 |
抄録: | Moyamoya disease (MMD) is a unique progressive steno-occlusive disease of the distal ends of bilateral internal arteries and their proximal branches. The difference in clinical symptoms between adult and children MMD patients has been well recognized. In this study, we sought to investigate the phenomenon through histopathological study. Fifty-one patients underwent surgical procedures for treatment of standard indications of MMD at Kyoto University Hospital. Fifty-nine specimens of MCA were obtained from MMD patients during the surgical procedures. Five MCA samples were also obtained in the same way from control patients. The samples were analyzed by histopathological methods. In this study, MCA specimens from MMD patients had significantly thinner media and thicker intima than control specimens. In subsequent analysis, adult (≥ 20 years) patients had thicker intima of MCA compared to pediatric (< 20 years) patients. There is no difference in internal elastic lamina pathology between adult and pediatric patients. Our results indicated that the pathological feature of MMD in tunica media occurs in both adult and pediatric patients. However, the MMD feature in tunica intima of MCA is more prominent in adult patients. Further analysis from MCA specimens and other researches are necessary to elucidate the pathophysiology of MMD. |
著作権等: | This article is applied Creative Commons Attribution Non-Commercial-NoDerivs License (CC BY-NC-ND) by the publisher. |
URI: | http://hdl.handle.net/2433/226832 |
DOI(出版社版): | 10.2176/nmc.oa.2016-0031 |
PubMed ID: | 27087193 |
出現コレクション: | 学術雑誌掲載論文等 |
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