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j.stemcr.2017.07.020.pdf | 2.92 MB | Adobe PDF | 見る/開く |
タイトル: | NK Cell Alloreactivity against KIR-Ligand-Mismatched HLA-Haploidentical Tissue Derived from HLA Haplotype-Homozygous iPSCs |
著者: | Ichise, Hiroshi https://orcid.org/0000-0002-3519-4947 (unconfirmed) Nagano, Seiji https://orcid.org/0000-0002-3519-4947 (unconfirmed) Maeda, Takuya Miyazaki, Masaki https://orcid.org/0000-0002-9543-624X (unconfirmed) Miyazaki, Yuki Kojima, Hiroto Yawata, Nobuyo Yawata, Makoto Tanaka, Hidenori Saji, Hiroh Masuda, Kyoko https://orcid.org/0000-0002-7670-9900 (unconfirmed) Kawamoto, Hiroshi https://orcid.org/0000-0002-7670-9900 (unconfirmed) |
著者名の別形: | 一瀬, 大志 永野, 誠治 宮崎, 正輝 増田, 喬子 河本, 宏 |
キーワード: | iPSCs NK cells KIR KIR ligand HLA-C transplantation regeneration vascular endothelial cells HLA haplotype-homozygote missing-self recognition |
発行日: | 12-Sep-2017 |
出版者: | Elsevier BV |
誌名: | Stem Cell Reports |
巻: | 9 |
号: | 3 |
開始ページ: | 853 |
終了ページ: | 867 |
抄録: | HLA haplotype-homozygous (HLA-homo) induced pluripotent stem cells (iPSCs) are being prepared to be used for allogeneic transplantation of regenerated tissue into recipients carrying an identical haplotype in one of the alleles (HLA-hetero). However, it remains unaddressed whether natural killer (NK) cells respond to these regenerated cells. HLA-C allotypes, known to serve as major ligands for inhibitory receptors of NK cells, can be classified into group 1 (C1) and group 2 (C2), based on their binding specificities. We found that the T cells and vascular endothelial cells regenerated from HLA-homo-C1/C1 iPSCs were killed by specific NK cell subsets from a putative HLA-hetero-C1/C2 recipient. Such cytotoxicity was canceled when target cells were regenerated from iPSCs transduced with the C2 gene identical to the recipient. These results clarify that NK cells can kill regenerated cells by sensing the lack of HLA-C expression and further provide the basis for an approach to prevent such NK cell-mediated rejection responses. |
記述: | iPS細胞から再生した細胞への免疫反応とその制御法 --今後のストック事業で起こりうる拒絶反応への対処法を提案--. 京都大学プレスリリース. 2017-09-01. |
著作権等: | © 2017 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
URI: | http://hdl.handle.net/2433/226956 |
DOI(出版社版): | 10.1016/j.stemcr.2017.07.020 |
PubMed ID: | 28867344 |
関連リンク: | https://www.kyoto-u.ac.jp/ja/research-news/2017-09-01-0 |
出現コレクション: | 学術雑誌掲載論文等 |
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