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Title: MHC matching improves engraftment of iPSC-derived neurons in non-human primates
Authors: Morizane, Asuka  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-7411-1828 (unconfirmed)
Kikuchi, Tetsuhiro  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-2332-4967 (unconfirmed)
Hayashi, Takuya
Mizuma, Hiroshi
Takara, Sayuki
Doi, Hisashi
Mawatari, Aya
Glasser, Matthew F.
Shiina, Takashi
Ishigaki, Hirohito
Itoh, Yasushi
Okita, Keisuke  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-5806-1090 (unconfirmed)
Yamasaki, Emi
Doi, Daisuke  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-0992-1220 (unconfirmed)
Onoe, Hirotaka
Ogasawara, Kazumasa
Yamanaka, Shinya  kyouindb  KAKEN_id
Takahashi, Jun  kyouindb  KAKEN_id
Author's alias: 森實, 飛鳥
菊地, 哲広
沖田, 圭介
山嵜, 絵海
土井, 大輔
尾上, 浩隆
山中, 伸弥
髙橋, 淳
Keywords: Allotransplantation
Induced pluripotent stem cells
Regeneration and repair in the nervous system
Stem-cell research
Issue Date: 30-Aug-2017
Publisher: Springer Nature
Journal title: Nature Communications
Volume: 8
Thesis number: 385
Abstract: The banking of human leukocyte antigen (HLA)-homozygous-induced pluripotent stem cells (iPSCs) is considered a future clinical strategy for HLA-matched cell transplantation to reduce immunological graft rejection. Here we show the efficacy of major histocompatibility complex (MHC)-matched allogeneic neural cell grafting in the brain, which is considered a less immune-responsive tissue, using iPSCs derived from an MHC homozygous cynomolgus macaque. Positron emission tomography imaging reveals neuroinflammation associated with an immune response against MHC-mismatched grafted cells. Immunohistological analyses reveal that MHC-matching reduces the immune response by suppressing the accumulation of microglia (Iba-1+) and lymphocytes (CD45+) into the grafts. Consequently, MHC-matching increases the survival of grafted dopamine neurons (tyrosine hydroxylase: TH+). The effect of an immunosuppressant, Tacrolimus, is also confirmed in the same experimental setting. Our results demonstrate the rationale for MHC-matching in neural cell grafting to the brain and its feasibility in a clinical setting.
Description: iPS細胞由来神経細胞の他家移植におけるMHC適合の有用性. 京都大学プレスリリース. 2017-09-04.
Rights: © The Author(s) 2017. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
URI: http://hdl.handle.net/2433/227001
DOI(Published Version): 10.1038/s41467-017-00926-5
PubMed ID: 28855509
Related Link: https://www.kyoto-u.ac.jp/ja/research-news/2017-09-04-1
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