ダウンロード数: 189
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
ijms.16090.pdf | 310.28 kB | Adobe PDF | 見る/開く |
タイトル: | Lower Body Mass Index is a Risk Factor for In-Hospital Mortality of Elderly Japanese Patients Treated with Ampicillin/sulbactam |
著者: | Miura, Makoto Kuwahara, Akiko Tomozawa, Akinori Omae, Naoki Yamamori, Motohiro Kadoyama, Kaori Sakaeda, Toshiyuki |
著者名の別形: | 栄田, 敏之 |
キーワード: | ampicillin/sulbactam elderly patients mortality body mass index |
発行日: | 19-Sep-2016 |
出版者: | Ivyspring International Publisher |
誌名: | International Journal of Medical Sciences |
巻: | 13 |
号: | 10 |
開始ページ: | 749 |
終了ページ: | 753 |
抄録: | Objectives: A retrospective examination was conducted to identify risk factors for in-hospital mortality of elderly patients (65 years or older) treated with the beta-lactam/beta-lactamase inhibitor combination antibiotic, ampicillin/sulbactam (ABPC/SBT). Methods: Clinical data from 96 patients who were hospitalized with infectious diseases and treated with ABPC/SBT (9 g/day or 12 g/day) were analyzed. Risk factors examined included demographic and clinical laboratory parameters. Parameter values prior to treatment and changes after treatment were compared between survivors and non-survivors. Results: The study patients had an average age of 81.9±8.4 years (±SD) and body mass index (BMI) of 19.9±4.2 kg/m2. They were characterized by anemia (low hemoglobin and hematocrit levels), inflammation (high leukocyte count, neutrophil count, C-reactive protein level, and body temperature), and hepatic and renal dysfunction (high aspartate aminotransferase, alanine aminotransferase and blood urea nitrogen levels). The BMI of non-survivors, 16.2±2.9 kg/m2, was lower than that of survivors, 20.4±4.1 kg/m2. In addition, the hematological parameters deteriorated more remarkably, inflammation markers were not altered (or the decrease was marginal), and hepatic function was not improved, in non-survivors. Conclusions: A lower BMI value is a risk factor for in-hospital mortality of elderly patients treated with ABPC/SBT. |
著作権等: | © Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions. |
URI: | http://hdl.handle.net/2433/227067 |
DOI(出版社版): | 10.7150/ijms.16090 |
PubMed ID: | 27766023 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。